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BIBC 102

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2. Oxidative phosphorylation in mitochondria. 3. Oxidative ... Glu Glycogen (glycogenesis) Figure 7-14b. 3 enzymes of glycogen breakdown (Glycogenolysis) ... – PowerPoint PPT presentation

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Title: BIBC 102


1
BIBC 102 Summer 2005 Lecture 4 August 8, 2005
2
Fig. 13.9
3
FORMATION OF ATP IN LIVING CELLS
1. Glycolysis 2. Oxidative phosphorylation in
mitochondria 3. Oxidative phosphorylation in
chloroplasts
4
BIOLOGICAL WORK
1. Activation of metabolism 2. Transport of
metabolites in and out of cells 3. Biosynthesis
of macromolecules DNA, RNA, protein,
polysaccharides 4. electrical signaling (nerve
cells) 5. Motility and force generation 6.
Regulatory mechanisms
5
Chapter 15 in Lehninger Glycolysis Catabolism
of Hexoses
6
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7
VV 16.5
8
acid-base catalysis in the isomerase reaction
9
VV 16.6
10
formation of a Schiff base as a covalent
intermediate in the aldolase reaction
11
VV 16.9
12
VV 16.10
13
LNC 15.7
14
LNC 15.8
15
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16
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17
THIAMINE PYROPHOSPHATE
VV 16.28
18
Metabolic flux and its control
19
LNC 15.16
20
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21
Phosphofructokinase 1
regulatory site
active site
active site
regulatory site
(only two of four subunits shown)
LNC 15.18a
22
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23
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24
Other sugars
  • Fructose
  • Galactose
  • Mannose

pp. 534-537 (Section 14.2) Feeder Pathways for
Glycolysis
25
Other Common Sugars
Monosaccharides fructose galactose mannose
Disaccharides sucrose Glu-Fru lactose Gal-Glu
maltose Glu-Glu trehalose Glu-Glu
26
Fig. 9.12 in LNC
27
Disaccharides
Galactose
Glucose
Figure 7-12
28
Glucose
Fructose
Figure 7-12
29
Glucose
Glucose
Figure 7-12
30
LNC 15.11
31
Lactose H2O D-galactose
D-glucoseSucrose H2O
D-fructose D-glucoseTrehalose H2O
2 D-glucose
Enzymes on surface of intestinal epithelial cells
Lactase
Sucrase
Trehalase
p. 535
32
Lactose IntoleranceOMIMOnline Mendelian
Inheritance in Man
33
Galactose to Glucose 1-P
Figure 14-11
34
Figure 14-11
35
p. 565
36
Figure 14-11
37
NADH H
NAD
Figure 14-11, p. 537
38
Enzymes required for galactose metabolism
kinase
Galactose Galactose 1-P
UDP-Glu
ATP ADP
Uridyl transferase
epimerase
UDP-Gal
Glucose 1-P
phosphoglucomutase
Glucose 6-P
39
GLYCOGEN METABOLISM
LNC Chapter 15
GLYCOGEN SYNTHESIS
LNC Chapter 20
40
Chapter 15 pp. 560-570(some figures from
Chapter 7) in Lehninger 4th ed.
  • Glycogen Metabolism

41
Catabolic PathwaysGlycogen ? Glu-6-P
(glycogenolysis)Glu-6-P ? Pyruvate
(glycolysis)Anabolic PathwaysPyruvate ? Glu
(gluconeogenesis)Glu ? Glycogen (glycogenesis)
42
Figure 7-14b
43
3 enzymes of glycogen breakdown(Glycogenolysis)
  1. glycogen phosphorylase
  2. glycogen debranching enzyme
  3. phosphoglucomutase

44
End of lecture 4, August 8, 2005
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