Mouse Genome Informatics

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Mouse Genome Informatics

• Susan McClatchy
• www.informatics.jax.org

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Schedule

• Introduction to MGI MTB and a few sample
  searches 30 minutes
• Self guided hands-on tutorial

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The Jackson LaboratoryBar Harbor, Maine
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The Jackson LaboratoryResearch Areas

• Aging
• Cancer
• Cardiovascular
• Computational Biology/Bioinformatics
• Genomics
• Immunology/Hematology
• Metabolic Disease Research
• Neurobiology
• Reproductive Developmental Biology

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Research Education at TJLwww.jax.org
Research areas and investigators
Courses, conferences and summer research
Mouse Genome Informatics
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MGI home pagewww.informatics.jax.org
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MGI is people powered

• 6 PIs
• gt 30 curators
• 25 software engineers, database administrators
  and support staff

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The process of curation
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Brca2tm1Mhun Allele Detail Page
Type of allele Original strain Mutation type and
description
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Brca2tm1Mhun Allele Detail Page
Mammalian Phenotype terms and notes
Link to reference
Human disease association
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Link to PubMed
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Brca2tm1Mhun Allele Detail Page
Link to human disease and mouse model detail page
Human disease association
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Breast Cancer Mouse Models
Mutations in these mouse genes associated with
phenotype resembling human breast cancer
Mutations in both mouse and human BRCA2 genes are
associated with breast cancer
Mutations in these human genes only associated
with breast cancer
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Breast Cancer Mouse Models
Combination of alleles
Strains
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Brca2 Gene Detail page
Genetic and physical maps data
Orthology
Sequences
Alleles, phenotypes human disease associations
Gene Ontology
Expression
Protein domains
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Mouse Tumor Biology
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Contact MGI User Support
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Live Demonstration www.informatics.jax.org