Missing data issues and extensions

1
Missing data issues and extensions

• For multilevel data we need to impute missing
  data for variables defined at higher levels
• We need to have a valid procedure for discrete
  variables
• Useful to include sampling weights
• Can we deal with partially missing data?

2
Consider the imputation stage with a set of
multivariate responses

• We illustrate first with a simple model where the
  response joint distribution is MVN and there are
  responses at 2 levels
• To illustrate how such a model is specified
  consider repeated measures of childrens heights
  level 2 is the childs adult height.

3
Child heights adult height

Child height as a cubic polynomial with intercept
slope random at level 2 and both correlated
with adult height random effect to give 3-variate
normal.
This allows us jointly to model level1 and level
2 variables with missing data. (see Goldstein and
Kounali, JRSSA, 2009)
4

• Results

Thus, if data are missing at either level 1 or
level 2 they will get imputed via the MCMC
algorithm.
5
Mixed response types

• For ordered, or unordered categorical data we can
  specify corresponding latent normal
  distributions.
• For ordered response we can consider a probit
  threshold model s.t.
• the cumulative probability of being in one of the
  categories 1,,s is
• and the associated latent normal model is

• For a p category unordered response we can
  define a latent p-1 variate normal

We can define MCMC steps to sample form observed
categorical responses an underlying normal or
MVN. Note that these are further conditioned on
the remaining set of (correlated) normal
variables. For details see Multilevel models with
multivariate mixed response types (2009)
Goldstein, H, Carpenter, J., Kenward, M., Levin,
K. Statistical Modelling (to appear)
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Imputation

• So now with any mixture of categorical and normal
  variables at any level, we sample, for each MCMC
  iteration, a MVN set of variables including
  imputed values.
• Thus imputation is standard and the reverse
  transformation is used to obtain imputed
  variables on the categorical scales.
• For non-normal continuous data we can use e.g. a
  Box-Cox normalising transformation to sample a
  latent normal. Further extensions for Poisson and
  other discrete distributions are also available.
• Release 2.10 of MLwiN has a link to REALCOM that
  allows these extensions.

7
Partially observed (coarsened) data

• Where we have a prior (estimated) probability
  distribution (PD) for a missing discrete (or
  continuous) variable value we simply insert an
  extra MCMC step that accepts the standard MI
  value with a probability that is just the
  probability given by the PD. A corresponding step
  is used for normal data.
• This thus uses all of the data efficiently. No
  data are discarded so long as it is possible to
  assign a PD.
• Applications in record matching, rating scales
  with uncertain responses etc.
• Several completed data sets are produced and
  combined as in standard MI

8
Sampling weights- briefly

• Consider a 2-level model
• Write level 2 weights as
• Level 1 weights for j-th level 2 unit as
• Final level 1 weights
• We use as the level 1 random part
  explanatory variable instead of the constant 1
• This will be used for imputation and for MOI

Ongoing work to incorporate this into
MLwiN-REALCOM