Lemongrass oil

1
????????????
Lemongrass oil
2
????????????????????

• 1. ????????? ??????????
• 2. ??????????? ????????
• 3. ????? ????????????
• 4. ?????? ????
• 5. ?????????? ?????

3
???????????? LEMONGRASS OIL

• ??????????????? Cybopogon citratus
• C. flexuosus
• ???? GRAMINEAE or
  POACEAE

4
???????? ?

• ?????? ?????????? ????????? ?????????
  ????? ??? ????? ???????? ????? ????? ????????
  ???????? Lapine, Lemongrass, West Indian
  lemongrass

5
??????????

• ???????? ??????? ??????????? ???????? ????

6
???????????????????

• ????????? ????????????????????????????????
  ??????????????? ?.?? - ?.? ????
• ????????? ????????????????? ????????? ?????
  ?-? ??. ??? ??-??? ??.
• ????????????????????? ??????????? ???????
  ????????????????????

7
????????????????????????????????? 6 ????

• ?????????? ????????????? ( Cybopogon citratus
  and C. flexuosus
• ????????? ???????????? ( papilioneae ,
  Ormosia robusta )
• ?????????
• ????????? ( Cybopogon nardus (Linn.) Rendle)
• ????????????
• ??????????????

8
??????????????????????????????????????
???????????????

• ????????? ???????????? ?????????????????????????
  ?? ??
• ??????????????? ????????????????????????????????
  ??????
• ????????????? ?????????????? citral
  ?????????????????

9
???????????

• ?????????????????????????????????????
  ?????????????????
• ??????????
• ???????????????????

10
???????????

• ???????? ????????? LD50/TD ??? 6.9
• ??????????????????????????? 2 ?????
  ??????????????? 20 ???? ????????????
• ?????????????????????????????????????????
  ???????? 2 ??????? ????????????????????????????
  ?????????? ??????????????????

11
??????????? (???)

• ??????????????????? (Cytotoxic acitivity)
  ???????????????????? ?????? (1 1) ??????????
  CA-9KB ??????????? 20 ?????????/????
  ????????????????????????????????
• ??????????????????? (Toxicity assessment)
  ????????????????????????????????????
  ????????????????????????????? 1 ?./??.

12
?????????? (Method of Administration)

• ????????????? ????????? ????? ????????????
• ????????

13
?????????

• ???????? (Antiseptic)
• ???????????????????? ????????????
• ????????????????
• ?????????????? ?????????????????
  ????????????????????????????????????????? ???????

14
????????? (???)

• ??????????????????????????????????????
• ??????????????????????

15
?????????????????????

• ???????????????????????? ???????????????
  ,?????????????????????????
• ??????????? Middle to Top note

16
???????? (Chemical composition)

• ???????????????????????????????? (Aldehyde
  volatile oil)

17
???????? C.flexuosus C.citratus Myrcene 0.46
8.2-19.2 Limonene 2.46 ????????? Linalool 1
.34 0.8-1.1 Citronellal (citral) 0.37 0.1
Geranyl acetate 1.95 1.00 Nerol 0.39 0.3-
0.4 Geraniol 3.80 0.5-0.4 Neral 30.06 2
5-28 Geranial 51.19 45.2-55.9 Citronellol 0
.44 0.1
18
??????????????????

• Antifungal
• Ovicidal ??? larvicidal
• antibacterial
• anti-inflammatory
• Vasorelaxation induced
• Antiviral
• ??????????????? GSH

19
?????????????? Repellency head lice

• ?????????????
• ??????????????????????? 3 ???? ?????????????????
  ???????? ????? 660 ?? (??? 110 ????????? 550 ??)
  ???? 6 -14 ??
• ???????????
• ???????? micro encapsulated ????????? 3.7
  ??????????????????????????????????????????????
  bipolymer ???????? (chitosan) ???? placebo ???
  ???????????????????????????? ?????????????????????
  ???????????

20
?????????????? Repellency head lice (???)

• ???????????????? 200 ml ?????????????????????????
  ???????????????????????????????????????????? 0.3
  ml ?????????????????????? 0.3 0.9 ml (1 -3
  ?????????) ????????????????????
  ?????????????????????????????????????????? ???? 6
  ????????????? ????????????????????????????????????
  ????????????????????????

21
?????????????????

• ??? placebo controlled double blind
• ????????????????????
• ?????????? SPSS 10.1 ???????????????? Fishers
  exact
• ??? McNemars test ???????????????????????????????
  ??????????????

22
??????????

• ??????????? 660 ?? ???? 550 ?? ??? 110 ??
• ?? 151 ?? (22.9) ??????????????
• ???? 133 ?? (20.1 ) ?????????????????????
• ????????????????????????????????????????? 7.4
  ???? (131/550, 16.7 ??? 4/110, 3.6 ????????)
• ?????????????????????????????????????? 13.2 ????
  (23.8 ??? 1.8 ????????) (P lt 0.001)

23
?????????? (???)

• ???????? 1 ???????????????????????????????????????
  ?????????????????
• ??? n ????? () ???????????() ????????()
• ??? 110 4 (3.6) 2 (1.8) 104 (94.6)
• ???? 550 147 (26.7) 131 (23.8) 272 (49.5)
• ??? ()660 151 (22.9) 133 (20.1) 376 (57.1)

24
?????????? (???)

• ???????????????? 2 ?? 2 ??????????
  ?????????????????????? 11 ?? 92 ?? (12.0)
  ????????????????? ?????????????? 51 ??? 101 ??
  (50.5) ????????? placebo (P lt 0.001)
• ???????????????? 3 ??????????? 2 ????? ???????
  12.4 (11/89) ????????????????????????????????
  33.7 (31/92) ???????????????? placebo (P lt
  0.001)

25
??????????????????