Lymphatic Filariasis Eradication

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• Lymphatic Filariasis Eradication
• Data Management
• Julian Buckmaster
• Northrop
  Grumman

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Introduction

• Julian Buckmaster
• Northrop Grumman
• Systems Analyst
• Lead for the Specimen
  Inventory Management System

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Why Data Management ?

• Accurate, consistent data, from end to end
• Minimize data entry errors
• Ensure specimens match patients
• Ensure test results match specimens
• Maximize data security
• Avoids the time and errors involved in
  transcribing paper forms
• Fast and accurate communication of specimen
  inventory test results
• Tracking of specimens from Field to Test Labs and
  Repository
• Pre printed labels applied at specimen source and
  bar code scanned to match patient and specimen

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Field Data Collection
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Field Office to Test Labs Taskforce
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Task Force Central Repository
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Field Field Office Tools

• Hand Held PDA
• Includes GPS and bar code scanner
• Custom software for recording location, patient
  demographics and human specimen information
• Custom software for recording mosquito
  collection information
• Software to synchronize with Laptop
• Laptop
• Software to synchronize with PDA
• Custom software for reviewing correcting field
  data, entering test data, Aliquoting, and
  creating shipments.
• Web Browser-based upload of all data to the Task
  Force

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Assay Test Lab Tools

• Personal Computer
• Web Browser based access to ASTRO 21C for
  receiving and sending shipments and all inventory
  management.
• Custom software for recording all test results
• Web Browser-based upload of test data to the
  Task Force

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Central Repository Tools

• Personal Computer
• Web Browser based access to ASTRO 21C for all
  specimen inventory management, including shipment
  monitoring and receipt.

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Task Force Tools

• Personal Computer
• Web Browser based access to ASTRO 21C to monitor
  the location and movement of all specimens in all
  locations.
• Custom database of all test results, patient
  information, specimen information (human
  mosquito), and location information.

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Data Organization (overview)
Location
ID Location Name Lat Long Notes . . . . .
Patient
ID First Name Last Name Location Lat Long .
. . . .
Specimen
ID Specimen Number Patient Type Drawn By
DateTime . . . . .
Aliquot
Unique ID Specimen ID Type Quantity DateTime
. . . . .
Test Result
ID Test Name Unique ID Value Observation
Tester DateTime Notes . .
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Labeling Solution

• Collectors will be supplied with pre-printed, bar
  coded labels
• All aliquots / vials have a pre-printed, bar
  coded CDC standard label applied
• Each aliquot of a single specimen must have a
  common specimen number and a unique Unique ID

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Specimen Inventory Management System
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ASTRO 21C Pedigree

• Developed for CDC by Northrop Grumman and its
  predecessors
• Is the software basis for CDC Repository (CASPIR)
• Used in 9 other CDC labs for specimen management
• Has been in production at CDC for 4 ½ years
• Currently contains
• 4 million aliquots
• 1.9 million specimens
• 11.7 million history events
• Supports
• 660 Collections
• 180 Projects
• 106 Principle Investigators

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Freezers managed by ASTRO 21C
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Picking Aliquots with ASTRO pick list
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Using ASTRO Box QA process
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ASTRO 21C Terminology

• Specimen
• Describes where the physical material originated
• Contains one or more aliquots
• Aliquot - Physical material belonging to a
  specimen
• Aliquot Unique ID
• 8 character base 36 identifier
• 2.8 Trillion numbers
• Uniquely identifies each aliquot in the system
• For example, A24XBZ9C

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ASTRO 21C Major Features

• ASTRO maintains
• All physical properties of aliquots
• Full life cycle history of aliquots
• Physical, organizational location properties
• Who updated and when
• Shipments
• Moving aliquots to and from locations such as
  Filed locations, Test Labs and the Repository.
• Security
• configurable by physical access, organizational
  rights and task to be performed
• Label printer and bar code reader integration

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Sample Screenshot - Box Contents
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ASTRO 21C Shipping

• Facilitates and records movement of aliquots
  between locations
• Guides the shipper and receiver through
• shipment creation
• assembly
• shipping
• receiving
• unpacking
• outgoing and incoming QA
• Transfers aliquot information to recipient

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Summary

• Data will be collected electronically,
  transmitted and updated electronically.
• ASTRO 21C will be at the core of the data
  management.
• Hand Held PDAs will be used for data gathering.
• Systems will be common across the whole project.
• Unique IDs on all aliquots is central to linking
  all material with tests, and the databases links
  all other information to these.
• Pre printed labels applied to all aliquots and
  scanned into hand held systems and ASTRO keep
  data accurate minimize errors.

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Questions
Lymphatic Filariasis Eradication Data Management

• Questions ?

Julian Buckmaster JBuckmaster_at_cdc.gov