Replicative cycle of HIV-1 and Therapy

1
Replicative cycle of HIV-1 and Therapy
Entry
Maturation
Reverse Transcription
Integration
2
Polymerase and RNase H active sites of HIV-1 RT
17-18 bp
p66
p51
3
p66
p51
4
DNA synthesis
dNTP
PPi
dNTP
PPi
DNAn
DNAn1
DNAn2 ...
5
Structures of NON-nucleoside analogue RT
inhibitors (NNRTIs)
6
HIV-1 RT Bound to a Non-Nucleoside RT
Inhibitor (NNRTI)
Active site
Nevirapine
7
HIV-1 RT Bound to a NNRTI Surrounding
NNRTI-associated Drug Resistance Mutations
Active site
Nevirapine
Drug resistance mutations
8
Structures of nucleoside analogue RT inhibitors
(NRTIs)
AZT
d4T
3TC
9
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10
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11
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12
HIV-1 RT Active Site and Nucleoside Analog Drug
Resistance Mutations
Active site
Drug resistance mutations
Incoming nucleotide
13
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14
HIV-1 Protease Bound to an Inhibitor
Active site
Substrate Cleft
Indinavir
15
HIV-1 Protease Bound to Inhibitor Drug
Resistance Mutations
Active site
Substrate Cleft
Major mutations
Indinavir
Minor mutations