Contribution Of Chloride Ion To The RMP

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Contribution Of Chloride Ion To The RMP

• By
• J. Razjouyan

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• Chloride- Potassium Equilibrium
• Experimental Behavior of Chloride on Resting
  Potential

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Chloride- Potassium Equilibrium(1)
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Chloride- Potassium Equilibrium(2)

• Role of Cl is secondary to that of K
• Small concentration of Cl in Intracellular
• Small change makes big changes( which is not True
  for potassium)
• Cl ion movement accommodate to K ion ratio
• KiCl-i KeCl-e
• Since the chloride ion ratio tracks the potassium
  ion ratio namely

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Experimental Behavior of Chloride on Resting
Potential(1)
-98.5 mV
Ke2.5 mM Cl-e120 mM
Ki140 mM Cl-i2.4 mM
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Experimental Behavior of Chloride on Resting
Potential(2)
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Experimental Behavior of Chloride on Resting
Potential(3)

• t 0-
• ECl EK
• EM -98.5
• t 0
• ECl -98.5mV ? -63.6 mV
• EM -77mV

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Experimental Behavior of Chloride on Resting
Potential(4)
Out Ke2.5 mM Cl-e120 mM ? 30 mM
In Ki140 mM Cl-i2.4 mM
Electric field
Concentration Gradient
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Experimental Behavior of Chloride on Resting
Potential(5)

• Equal flow ate of K and Cl drive forces
• F a 1/g

Research Showed that conductivity of K/Cl are
related.
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Experimental Behavior of Chloride on Resting
Potential(6)

• Cl in will reduce by ¼
• 2.4mM ? 0.6mM
• Kin will reduce from 140 to 140-2138.2
• EK will not change very much