1' Tay Sachs

1
1. Tay- Sachs
T t
T
TT
T t
¼ 25
t
T t
tt
2
2. Huntingtons
hh
Hh
hh
?
?
?
?
?
The individual genotypes or phenotypes can not be
determined but the probability of the disease
occurring can be determined. ( see next frame)
3
2. Huntingtons

• There is a 50 probability.

1/250
H h
h
Hh
hh
h
Hh
hh
4
3. A,B,O
iA iO
iA
iAiA
iAiO
iO
iAiO
iOiO
5
3. A,B,O
iA iO
iB
iAiB
iBiO
iO
iAiO
iOiO
6
3. A,B,O Blood
iA iO
iO
iAiO
iOiO
iO
iAiO
iOiO
7
4. Rh

• is dominant for Rh pos. , Rh neg. - is recessive

- -

-
-

-
-
8
4. Rh
- -

-
-
-
--
--
9
5. Hemophilia
XAY
?
XaY
10
5. Hemophilia

• Probability of hemophilia in male is 50
• but 25 overall

XA Y
XA
XAXA
XAY
Xa
XaY
XAXa
11
2Cystic Fibrosis
Cc
Cc
cc
cc
12
6. CF
C c
C
CC
Cc
¼ 25
c
Cc
cc
13
6. R-G Colorblindness
?
14
7. Red Green Colorblindness
XB Y
XB
XBXB
XBY
daughter
Xb
XbY
XBXb
15
(No Transcript)
16
7. Red Green Colorblindness
XB Y
XB
XBXB
XBY
daughter
Xb
XbY
XBXb
17
8. PKU

• There is a 25 chance of the occurrence.

E e
E
EE
Ee
¼ 25
e
Ee
ee
18
9. 50 or ½ in any pregnancy
X Y
X
XX
XY
X
XX
XY
19
10 Sickle Cell
ss
ss
Ss
20
Does this skip a generation ?
dd
21
Those with the disease could have two dominant or
only one dominant. You must look at the parents
and children.
d
D_
dd
Dd
Dd
22
bb
Bb Bb
Bb or BB
bb
23
Sex-Linked Inheritance
24
(No Transcript)
25
Aa X Aa
Aa or AA, aa aa, Aa or AA
26
B b
BB
Bb
B
b
bb
Bb
27

• Genes located next to each other on a chromosome
  will be inherited together

Linked Genes
Genes that are not linked
28
Human Genome Project

• Effort to determine location of and sequence of
  all human genes.
• 30,000

29
Test Cross

• To determine an unknown genotype cross the
  unknown with the dominant trait with a known
  homozygous recessive.

a a
A
A or a
Possible outcomes all Aa or ½ Aa and ½ aa.
30

• Chapter Review 363
• 1. b 11. picture of metaphase chrom.
• 2. a taken during mitosis and
• 3. c arranged by pairs 9 (often from
• 4. b tissue cultures)
• 5 d 12. The sex chromosomes determine
• 6. a an individuals sex the remaining
• 7. d chromosomes are autosomal.
• 8. c
• 9. a
• 10. a

31
Page 363 -14

• Mothers 1 and 6 are carriers. Person 3 can
  pass his affected X chromosome only to his
  daughters his sons inherit his Y chromosome
  and an X chromosome from their mother.

32
Page 363 - 15

• 15. No, because people with blood type A do not
  have the IB allele ( IAIB AB blood type )

33
Page 363- 16

• 16. Giving a person a transfusion of blood
  with the wrong Rh factor could be fatal.

34

• Page 365
• D
• B
• C
• A
• B
• E
• C