Understanding the Intersection Between Information Technology and the Life Sciences The Terrain

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Understanding the Intersection Between
Information Technology and the Life
SciencesThe Terrain
Bob RoyceVP Business Development
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I want to conquer death! I dont want to be sick!
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What is Bio-IT?
Information Technology
Life Sciences
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• Biology is an information science
• Leroy Hood,
• Michigan Life Science Core Technology Alliance
  Inauguration

In vivo
In silico
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• the language of
• biology is sounding increasingly like the
  language of systems engineering

MIT President Chuck Vest
103 of 341 MIT engineering school faculty use
the term bio to describe the nature of their
research.   Systems Biology at MIT Its All
Over the Place By Adrienne Burke, Genome
Technology editor-in-chief CAMBRIDGE, Mass., Jan.
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Scientific Process Information
Hypothesis -gt Experiment
Analysis
Design
Optimization/Archive
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DNA Where it all starts
The ultimate compression algorithm A 4 letter
code, 3 billion letters long contains the
recipe for building you and me
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Genomics to Proteomics
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From Genotype to Phenotype
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Complex, Deeply Nested Layers of Data
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All this Produces an Information Explosion
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That must be managed in a both a Public and
Private Context
Data Domain
no direct control of data format
Public
Partnerships/ Collaborations
moderate control of data format
Future
Present
Past
high level of control of data format
Internal
Static
Dynamic
Data Type
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In 50 percent of the interactions that I have
with vendors, they say, We have a
great technology that can help you.
Now tell me about drug discovery
Rainer Fuchs, vice president of research
informatics at Biogen

• There does seem to be a disconnect between
  the value proposition and what is offered,

Shawn Ramer, vice president of RD informatics at
Bristol-Myers Squibb
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Pharmaceutical RD
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Pharmaceutical RD
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Conclusion

• Current focus is on applied technology
• Must understand the drug discovery process.
• Complexity of industry should not be
  underestimated
• Pace of discovery and innovation is staggering
• Partnerships and alliances are key
• Nobody has the right model.
• Everybody knows they need new ways to solve the
  problem
• Fragmentation in solution space makes it
  difficult to get economies of scale for
  technology development
• But the goal is noble and the prize is large!