Early events of HIV infection in MDM

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Early events of HIV infection in MDM
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Conclusions perspectives

• Pseudotyped enveloped viruses depend on the
  acidic environment of endosomes.
• Fusion of the viral membrane with the endosomal
  membrane induces a productive HIV-1 infection.

• Hypothesis Hz stalls cellular trafficking
• The inhibition of late endosome recruitment
  prevents Hz degradation
• Productive HIV-1 infection is affected by the
  Hz-mediated endosome pathway disruption
• Short term objective cellular fractionation
  assays