Pathology of Viral Hepatitis

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Nearly all men can stand adversity, but if you
want to test a man's character, give him
power  Abraham Lincoln
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Pathology of Viral Hepatitis
Dr. Venkatesh M. Shashidhar. Senior Lecturer in
Pathology Fiji School of Medicine
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Introduction

• Inflammation of Liver
• Viral, immune, Drugs, Toxins other.
• Acute, Chronic Fulminant - types
• Viral Hepatitis
• Specific Heptitis A, B, C, D, E, other
• Systemic - CMV, EBV, other.

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Phases of Hepatitis

• Carrier state / Asymptomatic phase
• Acute hepatitis
• Chronic Hepatitis
• Chronic Persistent Hepatitis
• Chronic Active Hepatitis
• Fulminant hepatitis
• Cirrhosis

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Acute Hepatitis

• Incubation phase.
• Symptomatic pre-icteric phase.
• Symptomatic icteric phase.
• Convalescence.

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Acute Chronic

• Ballooning deg
• Cholestasis
• Apoptosis
• Periportal Necrosis
• Macrophages
• Inflammation
• Portal inflammation
• Fatty change(C)

• Ground glass (B)
• Apoptosis
• Periportal Necrosis
• Macrophages
• Portal Lymphoid infiltrate
• Bridging fibrosis
• Fatty change(C)

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Fulminant Hepatitis

• Hepatic failure with in 2-3 weeks.
• Reactivation of chronic or acute hepatitis
• Massive necrosis, shrinkage, wrinkled
• Collapsed reticulin network
• Only portal tracts visible
• Little or massive inflammation time
• More than a week regenerative activity
• Complete recovery or - cirrhosis.

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Hepatitis Morphology
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Hepatitis viruses(A,B,C,D,E,G other)
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Acute viral Hepatitis
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Acute viral Hepatitis
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Acute viral Hepatitis
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Acute viral Hepatitis
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Liver Biopsy viral Hepatitis-C
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Acute viral Hepatitis C
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Liver Biopsy CPH
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Liver Biopsy - CAH
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Liver Gross Cirrhosis
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Liver Biopsy Cirrhosis
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Liver Biopsy Cirrhosis
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Liver Biopsy Cirrhosis
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Thank You