Comparison of Acute and Chronic Inflammation

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Comparison of Acute and Chronic Inflammation
Process Acute Inflammation
Chronic Inflammation Initiators Microbial
surfaces fragments Non-digestable
organisms Injured tissue tissue
fragments Non-degradable foreign
matter Auto-immune reactions Mediators Mast
cell products (histamine) T-lymophocytes and
macrophage Bradykinin products- cytokines
and GFs Lysosomal components Proteases and
reactive oxygen Complement, lipid
mediators Complement, lipid mediators Cell
Neutrophils Monocytes/Macrophages Populations
Tissue macrophages Plasma cells,
Fibroblasts Time course Acute onset, minutes
?days Insidious onset, weeks ? years Outcome Reso
lution, Abscess formation Resolution, Tissue
destruction, Chronic inflammation fibrosis