Breast Health and PARPS

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• Breast Health and PARPS

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News Flash!

• PARP inhibitors are making headline news
• June 2009 Exciting Cancer News
• New Generation of Cancer Drug
• New Hope for Cancer Treatment
• PARP Inhibitors Shrink Certain Tumors

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Breast Health Spectrum

• Two Ends of the Breast Health Spectrum
• From identifying those at greatest risk of
  developing the disease to treating those with the
  most advanced disease 
• What are the medical breakthroughs?
• What are PARPs?

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Breast Cancer

• Are you at risk or at an
  increased risk for breast cancer?
• Age
• Age at the start of menstruation
• Age at first live birth
• Number of first-degree relatives (mother,
  sisters, daughters) with breast cancer
• Number of previous breast biopsies (whether
  positive or negative)
• At least one breast biopsy with atypical
  hyperplasia

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Breast Cancer

• Talk with your healthcare provider about your
  individual risk for developing breast cancer
• GAIL Risk score Determine yours today!
  http//www.cancer.gov/bcrisktool/

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Genetic Testing

• Should you consider genetic testing for breast
  cancer?
• Not every woman is a candidate for genetic
  testing
• The decision depends on the womans individual
  medical history and her familys medical history
• If you have genetic concerns, discuss options for
  genetic testing with your healthcare provider

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What are PARPs?

• Poly (ADP-ribose) Polymerase ? PARPs are making
  headline news, but what are they?
• PARP Is a ubiquitous nuclear enzyme whose
  function in the human body includes repairing
  damage to our DNA.
• PARP regulates the nuclear machinery used for
  repairing damaged DNA. If left unrepaired, DNA
  damage can stall the cell cycle and lead to cell
  death.

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What is a PARP Inhibitor?

• PARP inhibitors prevent cancer
• cells from repairing their own DNA.
• If we can inhibit this enzyme that
• repairs DNA and promotes healthy cell
• growth, we can potentially stop or
• interfere with the growth and production
• of cancer cells in the body.

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PARP Inhibitors

• Who will benefit from PARP inhibitors?
• Will all breast cancers be treated with this?
• PARPs are Targeted Agents for use in advanced
  breast cancer and in BRCA-associated cancer.

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Resources

• For information on Breast Cancer Risk and
  Genetic Testing, visit
• www.LancasterGeneralHealth.org
• To learn more about ongoing PARP Inhibitor
  clinical trials, visit
• breastcancer.org
• cancer.gov
• clinicaltrials.gov

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References

• National Cancer Institute www.cancer.gov
• Science of PARP http//www.biparsciences.com/0000
  10.html
• Journal of Clinical Oncology
• GAIL Risk Score http//www.cancer.gov/bcrisktool/
• BiPar Sciences manufacturer of BSI-201 a
  leading candidate in the field of PARP inhibitors
  and is the furthest along in clinical development
  of this novel therapeutic approach.
• American Society of Clinical Oncology (ASCO) 2009
  Meeting