Tutorial Question Respiration

1
Tutorial Question (Respiration)
Discuss the statement "The transport of oxygen
and carbon dioxide in human body do not interact
with each other."
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Question Analysis
Discuss the statement "The transport of oxygen
and carbon dioxide in human body do not interact
with each other."
Action Required
Discussion For or against the statement
Key Words
Transport of O2 and CO2
in human body
do not interact with each other
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Transport of O2 and CO2 in human body
Involvement of RBC, Hb and plasma different
roles in O2 and CO2 transport
Interaction Haldane Effect
Conclusive Remark The transport of O2 and CO2
do interect with each other..(next page)
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Transport of O2 and CO2 interact with each
other Tissue side H (from carbonic acids)
binds to oxy-Hb gt more unloading of O2 to
tissues (Bohr effect) gt more deoxy-Hb are
formed gt higher buffering ability (H binds
better to deoxy-Hb) gt more CO2 will be removed
(shift of the equilibrium CO2 H2O ------gt
H2CO3 -----gt H HCO3- )
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In the pulmonary side More oxy-Hb will be
formed gt lower affinity to H H released
from oxy-Hb gt HCO3- will be attracted to RBC
H2CO3 formed gt reverse of chloride
shift gt H2CO3 ----- gt CO2 H2O low PCO2 and
actions of carbonic anhydrase
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Haldane Effect Near tissues, low PO2 gt high
CO2 transportation Near the lungs, high PO2 gt
low CO2 transportation