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BB10a: Cells, Biomolecules

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Title: BB10a: Cells, Biomolecules


1
BB10a Cells, Biomolecules Genetics, 2003
Semester 1.
  • Thursday 2 Oct.
  • Lecture 4
  • Structures functions of common carbohydrates
  • Andrew Pearson

2
BB10A Common carbohydrates
Basic units called monosaccharides  are simple
sugars such as glucose and fructose. The
structures of monosaccharides can be drawn in
different ways, to highlight different
aspects   the Fischer projection is best for
showing the stereoisomerism of the various
substituents but the Howarth projection is more
useful to biochemists because it approximates the
3-D structures and helps explain stabilities.  
3
BB10A Common carbohydrates
Fischer projections
4
Properties of monosaccharides.  Containing many
hydroxyl groups sugars interact easily with
water they are hydrophilic
water-soluble. Containing many hydroxyl groups
sugars are highly oxidised and can be easily
hydrolysed into fragments. Containing many
hydroxyl groups sugars are easily derivatised
to give related molecules, including
aminosugars, acetylated sugars, dimers,
oligomers and polymers.
BB10A Common carbohydrates
5
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6
BB10A Common carbohydrates
7
BB10A Common carbohydrates
8
The relationship between the various isomers of
sugars is not complicated to biochemists
Biomolecules like sugars are selected because
of their 3-D structure, and the wrong isomer
simply does not fit into binding sites.   The
distinction between D- and L- glucose is not
something that many biochemists concern
themselves with nowadays some bacterial
products contain the odd L-sugar, all others are
D-.
BB10A Common carbohydrates
9
Precise 3dimensional fit between a substrate and
enzyme.
Ionic interaction
Hydrophobic Interaction
H-bond
Adapted From Voet Voet
10
BB10A Common carbohydrates
11
Disaccharides two monosaccharides joined
by O-glycosidic bond. Three occur naturally in
stable form, Lactose in breast milk (sugar
transport) Sucrose in plant sap (plant transport
sugar) Trehalose in fungi and insect heamolymph
(for transport) all others shown in books are
digestion products of something bigger.
BB10A Common carbohydrates
12
BB10A Common carbohydrates
13
BB10A Common carbohydrates
Disaccharides
maltose
trehalose
sucrose
cellobiose
lactose
14
BB10A Common carbohydrates
Glycogen, in animals, is similar but has
a greater degree of branching.
15
BB10A Common carbohydrates
Cellulose is a linear homopolymer of glucose, but
unlike amylose the O-glycosidic bond is beta in
cellulose alpha in amylose.
16
Cellulose note the H-bonds.
A tetrasaccharide from heparan sulphate note the
substituted sugars.
Repeating unit of chitin from insects and
crustaceans
17
The raffinose series at the end of a number of
unusual plant storage polysaccharides. Our
intestinal digestive enzymes are unable to cleave
stachyose into smaller units but anaerobes in
our lower intestines can..
BB10A Common carbohydrates
18
BB10A Common carbohydrates
19
The difference in size between proteoglycans whi
ch are giant macromolecules and glycoproteins,
which are small soluble protein
macromolecules.
BB10A Common carbohydrates
20
Just so stories how furanosides and pyranosides
got their names
BB10A Common carbohydrates
21
  • Functions of Monosaccharides
  •  
  • broken down for energy (by either fermentation
    or respiration)
  • interconverted/carbon skeleton used for
    biosyntheses
  • solvation of hydrophobes in aqueous transport
    media such as serum
  • transport form of energy in animal serum, plant
    sap and intracellularly in general.  

BB10A Common carbohydrates
22
  • Oligosaccharides
  • short branched heteropolymeric chains of
  • monosaccharides, often derivatised,
  • with high informational content in their normal
  • hydrated state.
  • Functions
  • markers for outer surface of cell membranes
  • protein targeting markers in endoplasmic
    reticulum system
  • prevention of membrane protein flip-flop
  • formation of glycocalyx

BB10A Common carbohydrates
23
Polysaccharides long chains of
monosaccharides, sometimes branched, either
Homopolymers (only one type of monosacch.)
(e.g. cellulose, glycogen, amylose,
amylopectin) or heteropolymers (more than one
monosacch.) (e.g. glycosaminoglycans, algal cell
wall gels, peptidoglycan, chitin)
BB10A Common carbohydrates
24
BB10A Common carbohydrates
  • Functions
  • energy reserves in plants
  • (starch and some of the flatulogenic polymers)
  • energy reserves in animals
  • glycogen
  • structural in all except animals
  • chitin, celluloses, peptidoglycan
  • lubrication and shock-absorbing
  • in synovial fluids, connective tissues

25
CHO function table
BB10A Common carbohydrates
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