A Patients Guide to Treatment

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• A Patients Guide to Treatment

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BOTOX Cosmetic Overview

• History of BOTOX Cosmetic
• How lines and wrinkles can form
• How BOTOX Cosmetic works
• What to expect from a BOTOX Cosmetic procedure

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BOTOX Cosmetic Overview contd

• Dramatic results with no downtime
• Dramatic results within a week
• Dramatic results that people notice
• Dramatic results that look natural
• BOTOX Cosmetic safety
• Summary

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BOTOX (Botulinum Toxin Type A)10 Years of
Success

• BOTOX is the only one of its type with over 10
  years of success in treating patients with a
  variety of conditions
• Approved in 70 countries for a broad range of
  conditions
• Currently being investigated in the US for the
  treatment of many medical conditions

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BOTOX CosmeticNOW FDA APPROVED!

• With dosing specific to treat frown lines, BOTOX
  is now available as BOTOX Cosmetic
• BOTOX Cosmetic is a highly effective procedure
  that can dramatically reduce wrinkles between
  your brows

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How Lines and Wrinkles Can Form

• Movement of brow muscles causes the skin to
  crease

• As skin becomes less elastic over time, repeated
  frowning creates visible lines and wrinkles

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• Ricki
• My daughter said that I was looking older and
  that I looked unhappyeven when I was
  smiling. I realized that I was looking older
  because of the frown lines that were
  developing between my brows.

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How BOTOX Cosmetic Works

• BOTOX Cosmetic is a natural and purified protein
  that relaxes the muscles by blocking nerve
  impulses

With a few tiny injections, BOTOX Cosmetic
blocks the release of acetylcholine, the
chemical thatcauses muscles to contract.

• Once the muscles are at rest, the skin becomes
  smoother, creating a more natural and relaxed
  appearance

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What to Expect From a BOTOX Cosmetic Procedure

• This simple 10-minute procedure consists of a few
  tiny injections
• No anesthesia is required, although you may be
  advised to numb the area with a cold pack or
  anesthetic cream prior to injecting
• Discomfort is minimal and briefmost patients
  compared the sensation to a bug bite
• There may be slight temporary bruising at the
  injection site, which can easily be covered up
  with makeup

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Dramatic Results With No Downtime

Unretouched clinical photos taken at maximum
frown before BOTOX Cosmetic and 30 days after
BOTOX Cosmetic treatment.

• After the procedure, you can resume normal
  activity immediately

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Dramatic Results Within a Week

• Youll see a marked improvement within days that
  may continue to improve for as long as a week
• In clinical studies, the majority of people
  (82.5) reported an improvement in the lines
  between their brows after a week (n405)
• The effects of BOTOX Cosmetic last up to 4 months

Unretouched clinical photos taken at maximum
frown before BOTOX Cosmetic and 30 days after
BOTOX Cosmetic treatment.
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• Donna
• I would definitely do it again. I make sure
  to schedule treatments every 3 to 4 months.
  Im pretty diligent about it because I feel
  like it makes a difference.

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Dramatic Results That People Notice

• After 30 days, nearly 90 of BOTOX Cosmetic
  patients surveyed rated the improvement in their
  brow lines as moderate to better
• For many patients, BOTOX Cosmetic virtually
  erases these lines

Unretouched clinical photos taken at maximum
frown before BOTOX Cosmetic and 30 days after
BOTOX Cosmetic treatment.
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• Ricki
• The results have been terrific. BOTOX
  Cosmetic has virtually removed the frown lines
  between my brows.

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Dramatic Results That Look Natural

• With BOTOX Cosmetic, you will not look like
  youve had work done. You can still frown,
  smile, or look surprised without the wrinkles
  and creases

DonnaI get compliments on my appearance,
but nobody can pinpoint exactly what Ive
done. I feel good about not doing something
thats very obvious, because I like appearing
natural. Thats important to me.
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BOTOX Cosmetic Safety

• Contraindicated in the presence of infection at
  the proposed injection site(s) and in
  individuals with known hypersensitivity to any
  ingredient in the formulation
• Safe and effective. The most common side effects
  are headache, respiratory infection, flu
  syndrome, temporary eyelid droop, and nausea
• Administered at very low doses, and the effects
  are usually confined to the injected area it
  does not travel throughout the body

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BOTOX Cosmetic Safety

• Less frequently occurring (lt3) adverse reactions
  included pain in the face, redness at the
  injection site, and muscle weakness
• These events are thought to be associated with
  the injection and occurred within the first week
• Full prescribing information has been provided to
  your doctor

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BOTOX CosmeticSummary

• BOTOX Cosmetic is a simple, 10-minute procedure
  that can dramatically reduce your frown lines
• No recuperation time is required
• Youll see a marked improvement within days, and
  effects last up to 4 months
• Treatment is safe and effective. The most common
  side effects are headache, respiratory
  infection, flu syndrome, temporary eyelid droop,
  and nausea

Questions to ask your doctor

• Am I a good candidate for BOTOX Cosmetic
  treatment?
• What is your experience in using BOTOX Cosmetic
  for frown lines?
• When can I expect to see results and how long
  will they last?