AEDs: Molecular and Cellular Mechanisms

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AEDs Molecular and Cellular Mechanisms

• ? Phenytoin, Carbamazepine
• Block voltage-dependent sodium channels at high
  firing frequencies
• ? Barbiturates
• Prolong GABA-mediated chloride channel openings
• Some blockade of voltage-dependent sodium
  channels
• ? Benzodiazepines
• Increase frequency of GABA-mediated chloride
  channel openings