Lecture 18 Humoral Immune Response

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Lecture 18Humoral Immune Response
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The Antibody Response
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Antibody Protection of the Host
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Immunologic Memory
Virgin lymphocyte pool
PRIMARY RESPONSE
effector cells
memory cell pool
SECONDARY RESPONSE
effector cells
memory cell pool
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Immunologically Naive
No previous experience No memory Must be educated
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The Primary Immune Response
antibody titer
lag
log phase
plateau
decline
time
antigen challenge
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Class Switching
antibdy titer
IgG
IgM
time
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Four phases of the primary response

• a lag phase where no antibody is detected
• a log phase in which the antibody titer rises
  logarithmically
• a plateau phase during which the antibody titer
  stabilizes
• a phase (decline) during which the antibody is
  cleared or catabilized

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The Anamnestic Immune Response
Secondary Response
antibody titer
1000
100
Primary Response
10
1
Time
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Comparison of Primary and Secondary Responses

• Time course
• Antibody titer
• Antibody class
• Antibody affinity

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Terms to remember

• Opsonization
• Neutralization
• Complement activation
• Primary response
• Secondary/ anamnestic/ booster response
• Lag phase
• Log phase
• Plateau period
• Memory cells
• Class switching
• Affinity maturation/ change in affinity with time