Archibald Garrod 1902

1
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• Archibald Garrod (1902)
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4
Alkaptonuria
Turns black in presence of oxygen
(alkapton)
5
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(Neurospora Beadle Tatum (1940s)
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6
(No Transcript)
7
Neurospora crassa
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8
Neurospora crassa

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9
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10

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Enzyme C
11
Enzymes and Genes

• If each step in the process depended on an
  enzyme, and each enzyme depended on a gene
• Mutations in any one gene would prevent
  production of the nutrient

12
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13
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14
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15
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16
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17
One Gene-One Polypeptide
a gene
b gene