Microcirculation: control of exchange with tissues

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Microcirculation control of exchange with tissues
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T P x r
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Capillary exchange

• Diffusion
• Filtration
• Pinocytosis

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J - DA dc/dx J -PS(Co Ci)
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Krogh cylinders
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For small molecules, diffusion is not a
limitation, so transport is flow limited. Large
molecules are limited by diffusion.
NaCl
Transport
Albumin
Flow
With increased diffusion distance, even small
molecules can be diffusion limited
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Pinocytosis
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Qf k (Pc pi) (Pi pp) Qf LpS(Pc
Pi) s(pp pi)
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