Atomic

1
Atomic Molecular BioNanotechnology G.Ali
Mansoori, Bio Chem Eng Dept.s Prime Grant
Support ARO, KU, UMSL, ANL
Problem Statement and Motivation

• Diamondoids and Gold Nanoparticle - based
  nanobiotechnology - Applications for Drug
  Delivery.
• Quantum and statistical mechanics of small
  systems - Development of ab initio models and
  equations of state of nanosystems. Phase
  transitions, fragmentations.
• Molecular dynamics simulation of nano systems -
  Non-extensivity and internal pressure anomaly.
• DNA-Dendrimers nano-cluster formation.

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Related Publications
Technical Approaches

• DNA-Dendrimer Nano-Cluster Electrostatics (CTNS,
  2005)
• Nonextensivity and Nonintensivity in Nanosystems
  - A Molecular Dynamics Sumulation J Comput
  Theort Nanoscience (CTNS,2005)
• Principles of Nanotechnology (Book) World
  Scientific Pub. Co (2005)
• Statistical Mechanical Modeling and its
  Application to Nanosystems Handbook of Theor
  Comput Nanoscience and Nanotechnology (2005)
• Phase-Transition and Fragmentation in
  Nano-Confined Fluids J Comput Theort
  Nanoscience (2005).
• Interatomic Potential Models for Nanostructures"
  Encycl Nanoscience Nanotechnology (2004).

• Nanoparticles-Protein Attachmrnt
• Nano-Imaging (AFM STM), Microelectrophoresis
• Ab Initio computations (Applications of Gaussian
  98)
• Nano-Systems Simulations (Molecular Dynamics)
• Nano-Thermodynamics and Statistical Mechanics

2
Integrating Nanostructures with Biological
Structures Investigators M. Stroscio, ECE and
BioE M. Dutta, ECE Prime Grant Support ARO,
NSF, AFOSR, SRC, DARPA, DHS
Problem Statement and Motivation

• Coupling manmade nanostructures with biological
  structures to monitor and control biological
  processes.
• For underlying concepts see Biological
  Nanostructures and Applications of Nanostructures
  in Biology Electrical, Mechanical, Optical
  Properties, edited by Michael A. Stroscio and
  Mitra Dutta (Kluwer, New York, 2004).

Technical Approach
Key Achievements and Future Goals

• Synthesis of nanostructures
• Binding nanostructures to manmade structures
• Modeling electrical, optical and mechanical
• properties of nanostructures
• Experimental characterization of intergated
  manmade
• nanostructure-biological structures

• Numerous manmade nanostructures have been
  functionalized with biomolecules
• Nanostructure-biomolecule complexes have been
  used to study a variety of biological structures
  including cells
• Interactions between nanostructures with
  biomolecules and with biological environments
  have been modeled for a wide variety of systems
• Ultimate goal is controlling biological systems
  at the nanoscale