Inferring genetic regulatory logic from expression data - PowerPoint PPT Presentation

1 / 11
About This Presentation
Title:

Inferring genetic regulatory logic from expression data

Description:

... genetic regulatory logic from expression data. Prepared by Chunhui CAI. Logic gates. Working principles of cis-regulatory elements. OR' logic. AND' logic. NOR' ... – PowerPoint PPT presentation

Number of Views:19
Avg rating:3.0/5.0
Slides: 12
Provided by: CMT76
Category:

less

Transcript and Presenter's Notes

Title: Inferring genetic regulatory logic from expression data


1
Inferring genetic regulatory logic from
expression data
  • Prepared by Chunhui CAI

2
Logic gates
  • Working principles of cis-regulatory elements
  • OR logic
  • AND logic
  • NOR logic
  • OR-NOR logic

3
Bayesian network
  • A probabilistic model
  • Use probability as a means to express uncertainty
    about modeling variables and their dependencies.

4
System and methods
  • The model of gene regulatory interactions
  • Xi regulator
  • Y regulatee
  • Ii intermediate variable
  • ?i binding probability

5
System and methods
6
System and methods
7
System and methods
  • OR model

8
System and methods
  • OR-NOR model

9
System and methods
  • Rules
  • Gene expression values two states
  • 0 not expressed
  • 1 expressed
  • Type of regulation
  • Simultaneous
  • Time delay

10
Result
  • Regulatory interactions of 20 genes of
    S.cerevisiae. The full arcs represent activatory
    regulation, the dashed arcs represent inhibitory
    regulation. The relationship between genes
    regulating one common gene is described by
    OR-function.

11
Discussion
  • Probabilistic or deterministic
  • Either Fitting of the expression data into
    state value (simply two states(0,1)?)
  • Or Determining the activation/repression logic
  • (Later) How good is our clustering method (need
    to improve and more expression data should be
    involved)
Write a Comment
User Comments (0)
About PowerShow.com