Interferons

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Interferons Dendritic Cells Pathogen Clearance
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Interferons (IFNs)
TYPE I
TYPE II
TYPE III
IFN-?
IFN-?, -?, -?, -?, -k, -???-???-?
IFN-?s (IL-28A, IL-28B, IL-29)
IFN?-R1 IFN?-R2
IFNA-R1 IFNA-R2c
IFN?-R1 IL-10R2
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Biological Properties of Interferons (IFNs)
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The Interferon-g Signaling Pathway
Slide courtesy of Dr. Ana Gamero
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Type I Interferon Signaling
IFNAR1
IFNAR2
Cytoplasm
vav
p85
PKC
MKK 3/6
IRS1/2
PI3K
Rac-1
mTOR
Stat13
Msk1
p38?
p70S6
Msk2
C3G
4E-BP1
Rap1
MapKapK3
MapKapK2
mRNA translation
histone phosphorylation
Nucleus
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ssRNA viruses EMCV, RSV, WNV
fibroblast
dsRNA virus reovirus
TLR3 expressed in intracelular vesicular
compartments in DCs and on the cell surface in
certain epithelial cells
Randall Goodbourn, J Gen Virol 89 1-47 (2008)
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Influenza, VSV
pDC
HSV
Influenza, VSV
HSV
Randall Goodbourn, J Gen Virol 89 1-47 (2008)
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EMCV
cDC
RNA helicases
Viral RNA generated in the cytoplasm by
uncoating, transcription or replication
NDV, VSV, SeV, Influenza
Randall Goodbourn, J Gen Virol 89 1-47 (2008)
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