Childhood Obesity and Adult CHD Risk

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Childhood Obesity and Adult CHD Risk

• Adapted fromBaker et al. N Engl J Med
  20073572329-2337

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Child Obesity Adult CHD Risk
Objective

• To investigate the association between excess
  weight in childhood and risk of coronary heart
  disease (CHD) in adulthood in a large cohort of
  people born in Denmark

Baker et al. N Engl J Med 20073572329-2337
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Child Obesity Adult CHD Risk
Study Design

• Children undergoing annual health examinations in
  Copenhagen, Denmark, from 1930-1976 (N276,835)
• Height and weight measurements were obtained at
  baseline to calculate body mass index (BMI)
• Follow-up performed at age 25 or in the year 1977

Baker et al. N Engl J Med 20073572329-2337
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Child Obesity Adult CHD Risk
All CHD Events During Adulthood
Baker et al. N Engl J Med 20073572329-2337
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Child Obesity Adult CHD Risk
Fatal vs Nonfatal CHD Events During Adulthood
Baker et al. N Engl J Med 20073572329-2337
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Child Obesity Adult CHD Risk
Mean BMI Values Ages 7-13
Baker et al. N Engl J Med 20073572329-2337
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Child Obesity Adult CHD Risk
Risk of Fatal or Nonfatal CHD in Adulthood
Baker et al. N Engl J Med 20073572329-2337
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Child Obesity Adult CHD Risk
Risk of Fatal or Nonfatal CHD in
AdulthoodAdjusted for Birth Weight
Baker et al. N Engl J Med 20073572329-2337
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Child Obesity Adult CHD Risk
Conclusions
In a large population-based cohort of children

• Increased body mass index values were associated
  with increased risk of CHD events in adulthood
• Each 1-unit increase in BMI z score from ages
  7-13 significantly increased event risk
• Small incremental weight gain was associated with
  increased risk, suggesting typical BMI
  classification scheme for children (85th-95th
  percentile on growth charts) may not be ideal

Baker et al. N Engl J Med 20073572329-2337