2. Metalation of p-Deficient Heteroaromatics

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2. Metalation of p-Deficient Heteroaromatics
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Metalation of p- Deficient Heteroaromatics. Bare
Pyridines. Acidity Considerations
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Nu- Addition to Pyridines. Synthetic Utility
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Directed ortho Metalation (DoM) Reactivity of
Pyridines
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C-based Pyridine DoM. DMG CONEt2 Synthetic
Application
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C-based Pyridine DoM. DMG CON-R HetRing
Annelation
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C-Based Methoxypyridine DoM. DMG CH(O-)NR2
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HetAtom - Based Pyridine DoM. DMG OCONR2
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HetAtom - Based Pyridine DoM. DMG OCONR2.
Methodology
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HetAtom - Based Pyridine DoM. DMG OCONR2.
Anionic ortho-Fries Rearrangement
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HetAtom - Based Pyridine DoM. DMG N-COt-Bu.
Synthetic Application
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HetAtom-Based Pyridine DoM. DMG F, Cl.
Catalytic Metalation. 3-Formyl-2-halopyridines
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HetAtom-Based Pyridine DoM. DMG F,
Cl. Methodological Results
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HetAtom-Based Pyridine DoM. DMG I, F.
Tandem DoM / Halogen Dance Reactions of
Iodopyridines
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HetAtom-Based Pyridine DoM. DMG SO2NR2,
SO2N-R Methodology and Application
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HetAtom-Based Quinoline DoM. DMG
OCONEt2 Methodology
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HetAtom - Based Quinoline DoM. DMG
N-COt-Bu. Methodology
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Diazine DoM. Pyrimidines, DMG OMe. Methodology
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Diazine DoM. Pyrimidines, DMG Cl. Methodology
and Synthetic Utility
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Diazine

DoM
. Application to Nucleosides
Diazine

DoM
. Application to Nucleosides
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Diazine DoM. Pyridazines, DMG Cl. Methodology
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Diazine DoM. Pyridazines, DMG Cl. Addition of
s- and n-BuLi
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Diazine DoM. Pyrazines, DMG CON-t-Bu,
N-COt-Bu Unusual Reactivity
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"I thought you said it was spot to spot."
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