G6PD Deficiency

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G6PD Deficiency
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G6PD Deficiency

• G6PD Deficiency is also called Glucose-6-phosphate
  Dehydrogenate.
• It is a common enzyme deficiency. There are about
  400 million people do have G6PD Deficiency.
• In Africa, theres one G6PD Deficient person per
  four people.

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Percent of people who have G6PD Deficiency
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G6PD Deficiency

• G6PD enzyme is located on sex chromosome X at q28
  locus. Thus, G6PD enzyme is X-linked gene.
• Males are more likely to have defective gene than
  females do because G6PD deficiency will only
  manifest itself in females when there are two
  defective copies of the gene in the genome. As
  long as there is one good copy of the G6PD gene
  in a female, a normal enzyme will be produced and
  this normal enzyme can then take over the
  function that the defective enzyme lacks.

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The q28 locus of the X-chromosome
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Hemolytic Anemia

• G6PD deficiency cause red blood cells no longer
  transport oxygen effectively throughout the body.
  This condition is called Hemolytic Anemia
  Arises.
• There are other conditions that also caused by
  G6PD deficiency- neonatal jaundice, abdominal
  back pain, dizziness, headache, irregular
  breathing, and palpitations.

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Hemolytic Anemia

• An anemic response can occur when G6PD deficient
  individual takes oxidative drugs or fava beans.
• Some G6PD deficient individuals are allergic to
  fava beans and the smell of the fava pollen.
  This condition is called Favism.

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The fava beans
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Diagnosis

• If a doctor suspects a G6PD deficiency on a
  new-born child, a Complete Blood Count or
  Screening Test is used to test and measure G6PD
  enzymes activity.

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Treatment

• Scientists can genetic engineer fava bean, so
  that it will no longer react to G6PD individuals
  red blood cells.
• The best treatment now to prevent favism and
  hemolytic anemia is to have drug control. G6PD
  deficient people should not eat fava beans or
  take drugs that contain oxidizing agent.

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The End