Hodgkin Lymphoma

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Hodgkin Lymphoma

• Dr. Nguy?n Anh Qu?c

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I. Definition

• Hodgkin Lymphoma is characterized by the presence
  of Reed Sternberg cells and their variants in an
  appropriate background of inflammatory cells. It
  includes two biologically and clinically distinct
  entities
• Nodular lymphocyte predominant Hodgkin
  Lymphoma (N-LPHL) is a B cell neoplasm .
• Classical Hodgkin Lymphoma (C-HC) presents a
  neoplasm of crippled B cells.

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II. Diagnostic Reed Sternberg cells

• They are large cells (20-30µm) with morphologic
  hallmarks of polyploidy (double multiple or
  multilobed nuclei).
• The nuclear membrane appears thick and there is a
  gigantic inclusion like eosinophilic nucleolus
  (larger than an erythrocyte) often surround by
  the halo. The cytoplasm is highly eosinophilic.

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III. Association with EBV

• gt 60 Hodgkin Lymphoma are associated with EBV
  and suggesting that EBV may play a even more
  important role in the genesis of Hodgkin Lymphoma
  when the level of immunocompetence is low.

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IV. Classification
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V. Clinical features

• Most patients present with lymphadenopathy. The
  enlarged nodes are often multiple, rubbery to
  firm, non tender and matted.

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VI. Treatment

• Chemotherapy and radiotherapy are effective in
  the treatment of HD. Treatment is determined
  largely by disease stage age at diagnosis and
  the presence of hilar lymphadenopathy or bulky
  nodal disease.

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VII. Prognosis

• 95 patient with favorable pronostic if they are
  used current therapeutic regimens.

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• Thanks for your attention