Protein Drug Delivery System

1
Protein Drug Delivery System

• Team Members
• Austin Ramme- Team Leader
• Michael Haggerty- BSAC
• Andrew Neumann- BWIG
• Sarajane Stevens- Team Leader-IT
• Becky Koszalinski- BSAC-IT
• Christopher Westphal- BWIG-IT

Advisor Professor Mitch Tyler
2
Presentation Outline

• Problem Statement
• Background Information
• Current Devices
• Research Competition
• Design Constraints
• Alternative Designs
• Future Work

3
Problem Statement

• Client Michael J. MacDonald, MD
• Diabetes Type I
• Protein Drug Delivery System
• Inexpensive
• Constant Injection Rate
• Disposable

4
Background Information

• Diabetes Type I
• Immune system
• Glucose level in the blood
• Juvenile onset diabetes
• Injections/Pumps

5
Background Information

• Insulin
• Protein-based drug
• Onset, peaktime, duration
• 5 to 10 units/day
• Unit 0.01 mL
• Protein Drugs
• Skin, ingestion, injection
• Injection sites

6
Current Devices Insulin Pumps

• Insulin syringe (3)
• Battery operated pump (2)
• Computer controlled
• Infusion set (1)
• Tube
• Needle (soft or metal)
• Very expensive (5,000 7,500)

7
Research Competition

• Professor Beebe
• Hydrogels
• Stimuli cause expansion in gel
• Currently toxic
• Non-linear expansion
• Wound-dressings
• Easy to mold

8
Suggested Materials

• Metering Valves
• Controls flow
• Chromatography
• NanoMuscles
• Contract like human muscle
• Rotational or linear motion
• Expandable Materials

9
Design Constraints

• Inexpensive
• Disposable
• Sterile
• Constant flow
• 8-24 hour delivery time
• Scaled up prototype

10
Design I Constant Pressure Device
60mm
15mm
Drug Reservoir
To Infusion Set
Metering Valve

• Disk shaped reservoir (60mm diameter)
• Spring applies constant pressure
• Metering valve controls flow rate

11
Design I Advantages Disadvantages

• Advantages
• Compact
• Flexible
• Cost efficient

• Disadvantages
• Awkward
• Health risks
• Advanced technology

12
Design II Bulb Gravity Box

• Ten scale
• Two chamber
• Separation membrane
• Uses gravity
• Air pressure
• Adhesive

One-Way Valve
Air Bulb
Metering Valve
Needle
Diaphragm
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Design II Advantages Disadvantages

• Advantages
• Easy filling
• Inexpensive materials
• Constant flow rate

Chamber 2

• Disadvantages
• Patient interactions
• Separation membrane
• Bulkiness

Chamber 1
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Design III NanoMuscle-Monstrosity (NMM)

• Batteries in series
• NanoMuscle
• Syringe
• Wire-Needle
• Flesh colored tube
• Adhesive undercoating

15
Design III Advantages Disadvantages

• Advantages
• Refilling procedure
• Materials
• NanoMuscles

• Disadvantages
• NanoMuscles
• Shape/Size

16
Future Work

• Flow rate and pressure calculations
• NanoMuscle research
• Metering valve search
• Constructing prototype
• Test prototype

17
References

• 1 Ahern J, Mazur ML. Apr 2001. Site Rotation.
  Diabetes Forecast. 54,466-68.
• 2 Anonymous. Jan 2004. Insulin Administration.
  Diabetes Care. 27S106-S109.
• 3 The Basics of Insulin. American Diabetes
  Association. 16 Sept 2004. lthttp//www.diabetes.o
  rg/type-1-diabetes/basics.jspgt.
• 4 Campbell, R. Keith. Update on Insulin
  Injection Devices. U.S. Pharmacist. 16 Sept
  2004. lthttp//www.uspharmacist.com/oldformat.asp?u
  rlnewlook/files/Feat/may00insulin.cfmgt.
• 5 Diabetes Mellitus. Microsoft Encarta
  Online Encyclopedia 2004. 10 Sept 2004.
• lthttp//encarta.msn.comgt.
• 6 Flow Rate Calculations. 15 Sept. 2004.
  lthttp//www.ecsel.psu.edu/tac167/flowcalcs.htmLgt.
  
• 7 Fluid Systems. 15 Sept 2004.
  lthttp//claymor.engineer.gvsu.edu/jackh/books/mode
  l/chapters/fluids.pdfgt.
• 8 Fomo Products, Inc. 24 Sept 2004.
  lthttp//www.fomo.com/msds/a16150.pdf gt.
• 9 Hydrostatic Pressure in a Liquid. 15 Sept
  2004. lthttp//www.ac.wwu.edu/vawtr/PhysicsNet/Top
  ics/Pressure/Hydrostatic.htmLgt.
• 10 Insulin Routines. American Diabetes
  Association. 16 Sept 2004 lthttp//www.diabetes.o
  rg/type-1-diabetes/injections.jspgt.
• 11 Insulin Storage and Syringe Safety
  Information. American Diabetes Association. 16
  Sept 2004. lthttp//www.diabetes.org/type-1-diabet
  es/safety.jspgt.
• 12 Insulin Pump 101. 19 Sept 2004.
  lthttp//www.banting.com/tcenter/pump101.htmLgt.
• 13 Insulin Pumps. American Diabetes
  Association. 10 Sept 2004. http//www.diabetes.or
  g/type-1-diabetes/insulin-pumps.jsp
• 14 Lumber T. Jul 2004. Tips for Site Rotation.
  Diabetes Forecast. 57,768-70.
• 15 Kempinger, Jayson. Personal Interview
  Austin Ramme. 25 Sept 2004.
• 16 Micro-Forged Metering Valves. Hoke, Inc. 15
  Sept 2004. lthttp//www.hoke.com/pdf/1600_series.p
  dfgt.
• 17 Micro Needle Valves. Scientific Instrument
  Services. 15 Sept 2004. lthttp//www.sisweb.com/c
  atalog/?pageD64gt.
• 18 Nanomucles. 21 Sept 2004.
  lthttp//www.nanomuscle.com/products/tech.htmLgt.

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Questions?