Proposition: One of the Motivations of Nano is to Engineer new Materials, Devices and Machines New T

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Proposition One of the Motivations of Nano is
to Engineer new Materials, Devices and
MachinesNew Technologies
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Engineering
So Why all of this biology? Do Mechanical
Engineers or Civil Engineers or Electrical
Engineers need to learn biology to do their
jobs?
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Nanotechnology Big Question1How do we build
materials or machines at the nanoscale ?
Can we just scale down macroscopic machine design?
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Lets say you could.
Macroscopic Motor. Will a nanoscopic version of
this motor work?
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Lets say the motor worked, would the nano-car go
?
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Proteins Natures NanomachinesThey work.
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In a very sticky, very shaky, very bumpy world.
How do they do this? (if you know the answer,
please come talk to me after class.)
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ATP Synthasebiology and nanotechnology
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ATP synthase is a machine that makes ATP. They
occur within the mitochondria at the inner
mitocondrial membrane.
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General Features of a Eukaryotic Cell
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Mitochondria The Power Plant (produces ATP)
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Metabolism in Mitochondria
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ATP Synthase is a protein machine

• Fairly recently, it has been determined that ATP
  synthase is a mechanical rotary motor
• It is very closely related to the motor that
  powers flagellar motion

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Bacterial Motility Flagellaswimming rhodobacter
spheroides
Armitage, J.P., and Schmitt, R. Microbiology 143,
3671-3682 (1997). http//www.rowland.org/labs/bac
teria/movies_rsphe.html
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Proteins are made of amino acids
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A protein is a chain of amino acids
That fold into a particular shape
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Amino Group
Carboxyl Group
Peptide Bond Formation
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Group 2 Kyle Cysteine Eli Glutamine Philip H. Gl
utamic Acid Jen Glycine
Group 1 Anthony Alanine Rachel Arginine John
F. Asparagine Arthur Aspartic Acid
Group 3 Philip M. Histidine Ben Isoleucine Jonat
han Leucine Todd Lysine
Group 4 John T. Methionine Andy
T. Phenylalanine Josh Proline Jordan Serine
Group 5 Chris Threonine Emily Tryptophan Feifei
Tyrosine Andy Y. Valine
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Each of you will build your amino acid. Then
within your group you will form peptide bonds
between your amino acids to create a small
protein or poly-peptide.