Classes of interspersed repeats in the human genome

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Classes of interspersed repeats in the human
genome
Fraction of genome
Copy number
Length
ORF1 ORF2(pol)
6-8 kb 850,000 21
Autonomous
LINEs
A B
SINEs
Non-autonomous
100-300 bp 1,500,000 13
gag pol (env)
6-11 kb
Autonomous
Retrovirus- like elements
450,000 8
(gag)
1.5-3 kb
Non-autonomous

transposase
Autonomous
2-3 kb
DNA transposon fossils
300,000 3
Non-autonomous
80-3,000 bp
Retrotransposon promoter element (when transposed
into DNA)
DNA transposon inverted terminal repeats
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Barbara McClintock
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(No Transcript)
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Exon shuffling by DNA transposase transposition
Fig. 10-18
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From UW- Madison web page
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Fig. 4-43
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Ch 4 page 133
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How do we know that the LTR retrotransponsons
transpose through an RNA intermediate?
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Fig. 10-14
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DNA Transposon from maize
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LTR
LTR
Retrotransposon coding sequence
Recombination

chromosome
lost from chromosome
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Fig. 4-33
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Fig. 4-34
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Parental strand
RNA primer
Lagging daughter strand
DNA Pol
DNA Pol
DNA Ligase
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Fig. 10-19
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Fig. 10-19
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(No Transcript)
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Fig. 10-20
H2A yellow, H2B red, H3 blue, H4 green
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Slide 2
Slide 2
Fig. 10-21