ATM/p53 Signaling Pathway

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ATM/p53 Signaling Pathway
SIGMA-ALDRICH
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ATM/p53 Signaling Pathway The ataxia
telangiectasia-mutated gene (ATM) encodes a
protein kinase that acts as a tumor suppressor.
ATM activation, via IR damage to DNA, stimulates
DNA repair and blocks cell cycle progression. One
mechanism through which this occurs is ATM
dependent phosphorylation of p53. p53 can cause
growth arrest of the cell at a checkpoint to
allow for DNA damage repair or can cause the cell
to undergo apoptosis if the damage cannot be
repaired. The critical role of p53 is evident by
the fact that it is mutated in over 50 of all
human cancers.