D' PAVIA

1
D. PAVIA CHEM 425a/552
NATURAL PRODUCTS CHEMISTRY
THE CHERRY PROBLEM
Using isotope labelling, the biosynthesis of
lophocerine in the cactus Lophocereus schottii
has been shown to result from a combination
of the amino acids leucine and tyrosine.
leucine
tyrosine
lophocerine
Suggest a stepwise biosynthetic route from the
suggested precursors to lophocerine. Label each
step with the responsible coenzyme or
enzyme where they are known.