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WRITING A GRANT AS A YOUNG INVESTIGATOR

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... 2-3 years at NIH; 2-3 years at extramural academic institution in U.S. ... grants only in response ... to submit well thought out project in short time frame ... – PowerPoint PPT presentation

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Title: WRITING A GRANT AS A YOUNG INVESTIGATOR


1
WRITING A GRANT AS A YOUNG INVESTIGATOR
Kay Ryan Director, Clinical Research
Operations MGH Clinical Research Program January
29, 2008
2
Todays Goals
1. Resources for Clinical Investigators 2.
Tips 3. Grants for starting Investigators NIH
Training Grants NIH Career Development
Awards Foundations
3
Resources for Clinical Investigators
  • MGH Clinical Research Program
  • CRP faculty mentors (Genomic/Genetic research
    Outcomes/Epidemiology research Biostatistical
    study design issues)
  • IRB submission consultation and advice
  • Implementing clinical studies budgeting clinical
    studies locating funding sources
  • Help with NIH and other federal submissions
  • Contact Kay Ryan (kryan10_at_partners.org)

4
More Resources
  • PHS Human Research Committee (HRC)
  • Guidelines, Forms, Certification, etc
  • http//healthcare.partners.org/phsirb/home.htm
  • Advice Maria Sundquist, PHS HRC
  • Denise McCauley, MGH Clinical
    Research Program
  • Research Management
  • Staff contacts, Forms, Policies, Deadline
  • http//phsresearchintranet.partners.org/PHS_Resea
    rchMgmt/RM_Contacts_MGH.asp

5
Tips
  • Identify at least 2 potential funding
  • sources for every project idea
  • 2. Dont rely on federal funding check
  • foundation databases
  • 3. Anticipate a re-submission
  • 3. Prepare a Letter of Intent (LOI)
  • LOIs used by foundations feds
  • 4. Start writing early, identify
    mentors/reviewers

6
Federal Grants for Different Career Stages MD
T32 or F32
K08 or K23
K22
K02
K24
R37
T35
R01
Independent PI
Medical Student
Clinical Training
Faculty Position
MD
K02 - Independent Scientist Award K24 -
Mid-Career Investigator Award Clinical
Research R37 - Merit Award
T35 - short-term, health prof students T32 -
Institutional Training Grant F32 - Individual
Postdoctoral Fellowship K08 - Mentored Clinical
Scientist Devt Award K23 - Mentored Clinical
Research Devt Award K22 - Research Scholar Devt
Award R03 Small Grant R21 Exploratory
Grant
7
NIH Career Development Programs (K Awards)
  • 14 Different Mechanisms
  • articulate with Career Stage
  • Mentored, Mid-career, Senior
  • interact with other NIH Awards
  • use K Kiosk or Career Award Wizard
  • http//grants.nih.gov/training
  • Note Not every NIH institute offers K awards

8
Know your NIH Institute!
  • Look at NIH Institute-specific websites (for
    example www.niddk.nih.gov )
  • Learn Institutes research priorities
  • Look at Institutes application success rates (
    applications awards)
  • http//grants1.nih.gov/grants/award/success.ht
    m

9
NIH Career Development Programs (K Awards)
  • 14 Different Mechanisms
  • articulate with Career Stage
  • Mentored, Mid-career, Senior
  • interact with other NIH Awards
  • use K Kiosk or Career Award Wizard
    http//grants.nih.gov/training

10
Career or K-series Awards
  • designed to protect time, i.e., free up time
    currently spent in clinic or on administrative or
    teaching duties
  • most are for early career development
  • provide salary not stipend
  • meant to train U.S. citizens/permanent residents
  • K99 is an exception to this policy
  • limited to U.S. research/clinical institutions

11
Career Development (K-series) Awards
  • K01 Mentored Research Scientist Development
    Award (Ph.D.)- usually basic research
  • K08 Mentored Clinical Scientist Development
    Award (M.D. or other clinical degree)- usually
    basic research
  • K99/R00 Pathway to Independence (PI) Awards
  • K23 Mentored Patient-oriented Research Career
    Development Award (M.D. or other clinical degree)
  • K22- Transition Award- 2-3 years at NIH 2-3
    years at extramural academic institution in U.S.
  • K24 Mid-Career Investigator Award in
    Patient-oriented Research (M.D.)

12
Career Development Mechanisms Aimed Primarily at
Clinical Scientists
  • Mentored Clinical Scientist Career Development
    Award (K08)
  • usually apply toward the end of fellowship
    training
  • 2-5 years of training in research
  • up to 75,000 per year in salary, up to 25,000
    per year in research-related costs
  • 3-5 year award
  • traditionally, not necessarily, basic research

13
Career Development Mechanisms Primarily Aimed at
Clinical Scientists
  • Mentored Patient-Oriented Career Development
    Award (K23)
  • encourage career development of physician
    scientists in clinical research
  • Senior Postdoctoral fellows
  • up to 75,000 per year in salary, and
    25,000-50,000 per year in research-related
    costs
  • 3-5 year award

14
Mentored Clinical Scientist Development Awards
(K08/K23)
  • mentor-based, bridge to independence
  • discrete research plan with plan for independence
  • this is NOT Post-Doctoral training
  • should have finished clinical training
  • Institutional support (promotion to Instructor?)
  • minimum 75 effort
  • 3-5 years of support
  • may also apply for (and receive!) R01 grant while
    holding a K award

15
NIH Application Resources
  • Sample K award applications
  • K08 http//www.nhlbi.nih.gov/funding/training/red
    book/k08model.htm
  • K23 http//www.nhlbi.nih.gov/funding/training/red
    book/k23models.htm

16
NIH Pathway to Independence (PI) Awards
(K99/R00)
  • provides up to 5 years of support in two phases
  • K99 Provides an intensive, mentored research
    experience for up to 2 years
  • R00 Independent scientist phase transition to
    research independence as junior faculty (up to 3
    years of support)
  • move to different Institution is generally the
    goal

17
Mentored Clinical Scientist Career Development
Award (K08/K23/K99)
  • Essential components of grant application
  • career development plan must be carefully
    documented
  • may include coursework
  • may work toward a graduate degree
  • mentorship must be strong and appropriate
  • Institutional commitment to career development
    must be clear

18
R-series grants
  • R01s Research project grants unsolicited and in
    response to Funding Opportunity Announcements
    (e.g. PAs and RFAs)
  • R21s Exploratory/Developmental grants usually
    only in response to FOAs
  • R03s Small grants only in response to FOAs
  • Subscribe to NIH Guide weekly announcement of
    NIH funding opportunities
  • email NIHTOC-L_at_LIST.NIH.GOV

19
The Letter of Intent (LOI)
  • Used by federal agencies/foundations
  • Filter applications to their interest area
  • Appoint appropriate reviewers
  • Specific to the agency, typically ask for
  • - Abstract
  • - NIH CV /Biosketch
  • - Nomination letter (some, but not all)

20
Writing an LOI- Start Early
  • Limited to 2 to 3 pages
  • Title of proposal
  • Abstract ( 200 words)
  • Background of applicant (or NIH Biosketch)
  • Objectives
  • Methodology
  • Statistical analysis plan
  • Key references

21
LOI can help you
  • crystallize the essence of the project
  • organize key references
  • get spring loaded to submit well thought out
    project in short time frame
  • Scope of work can be adjusted to funding

22
LOIs
  • Theyre Not Easy !
  • If I had more time, I would have written
  • you a shorter letter.
  • Mark Twain

23
Acknowledgements
  • Recent Extensive Presentations by
  • William F. Crowley, Jr. , MD
  • How to write a ucceful NIH grant
  • Janet E. Hall, MD
  • Writing your first investigator initiated grant
    as a Young Investigator
  • Available on CRP website.

24
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