Ligand-Gated Ion Channel: Structure and Activation States

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Ligand-Gated Ion Channel Structure and
Activation States
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Ligand-Gated Ion Channel Structure and
Activation States

• The intrinsic ion channel in this superfamily of
  receptors undergoes a conformational change
  following the binding of an extracellular ligand
  to its binding site, which allows for the opening
  of the channel pore.
• The pore is formed by a pentameric arrangement of
  subunits, which are in turn composed of a large
  extracellular domain (which contains the ligand
  binding site) and four transmembrane domains.