MODERATION, BALANCE FOR YOU

1
In His Image
T E M P E R A N C E
P r o g r a m
LIFESTYLE PRINCIPLES FOR THE 21ST CENTURY
MODERATION, BALANCE FOR YOU
T E M P E R A N C E
Presents MargiAnne Isaia, MD, MPH
Design Gabriel Isaia
Apex Concepts, Loma Linda CA USA
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IN HIS IMAGE
Temperance
T E M P E R A N C E
ABSTINENCE
Dispense with everything hurtful
MODERATION
Judiciously use that which is healthy
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IN HIS IMAGE
Temperance
BRAIN REGIONS AND THEIR FUNCTIONS
Certain parts of the brain govern specific
functions Example cerebellum
coordination Hippocampus memory
uu Neurons (nerve cells) basic unit of
communication in the brain uu Neurotransmission
information relayed from one area to another
areas 4 Via electrical impulses 4 Through
complex circuits 4 Using neurotransmitters
(NT)
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IN HIS IMAGE
Temperance
THE REWARD PATHWAY
FUNCTION --- provides a reward and associated
pleasurable feeling for performing
activities that keep us alive
MADE OF network of neurons in
Ventral tegmental area VTA
Nucleus accumbens NA
Prefrontal cortex
HOW IT WORKS
Rewarding stimulus g
Brain reward circuit g Effect
(pleasure)
(neurotransmission)

• Rewarding Stimulus

natural food, water, sex
non-natural (addictive agent) drugs,
non-drugs
(even greater feelings of pleasure than natural
stimulus)
NT (neurotransmitter) - Dopamine
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IN HIS IMAGE
Temperance
THE REWARD PATHWAY
NORMAL COMMUNICATION PROCESS BETWEEN NEURONS
Dopamine (DA) -- released by neuron into a
synapse (the gap between neurons)
-- binds to a receptor (RDA) on the neighboring
neurons
-- information (signal) -- released to that
neuron.
-- DA transported back by DA transporter
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IN HIS IMAGE
Abstinence
THE REWARD PATHWAY
D R U G S
act through dopamine (DA)
Cocaine --- block DA transporter --- continuous
stimulation of the receiving neuron --- euphoric
effect
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IN HIS IMAGE
Abstinence
D R U G S
ALTER THE PHYSIOLOGY OF NEUROTRANSMITTERS
In the reward pathway
h DA concentration g continuous stimulation g
addiction
Drugs cocaine, opiates, caffeine, nicotine,
amphetamine, teophyline, teobromine

• NE, 5HT cocaine, amphetamines
• NE, 5HT, GABA opiates (morphine, heroine,
  methadone)
• 5HT marijuana, hallucinogens, PCP, ketamine
• Ach caffeine, nicotine
• GABA ethanol, barbiturate, benzodiazepines
• glutamate nicotine
• iAdenosine caffeine

In other brain areas
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IN HIS IMAGE
Abstinence
ADDICTION
P R O C E S S
from a REAL WORLD
to an UNREAL WORLD
DA main neurotransmitter (NT) in the
addictions pathways
Serotonin 5HT role in the addictions
pathway owning to its regulation of impulse
control
pharmacological
addiction

• Addictive agents chemicals
• alcohol, nicotine, caffeine, cocaine, heroine,
  morphine, LSD, mescaline, methamphetamine

psychological

• Addictive agents non-chemicals
• work, achievements, success, money, gambling, TV,
  computer games, sex, harmful relationships,
  literature (fiction), bad music
• New interest, food addiction meat, cheese, sugar

psychological
addiction
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IN HIS IMAGE
Abstinence
Other areas of brain (less glucose, less active)
D R U G S
Disruption of many brain functions
Damage the brain structure (decrease the size of
neurons)
Entering blood stream
Damage body organs and systems
PLEASURE
PHYSICAL DISORDERS
But bypassing surviving activities
MENTAL DISORDERS
SOCIAL DISORDERS
SPIRITUAL DISORDERS
DEATH
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IN HIS IMAGE
Abstinence
A L C O H O L
is closely linked with virtually every negative
aspect of society
suicide, violent crime, birth defects,
industrial accidents, domestic sexual abuse,
disease, homelessness and death
It is the number 1 drug problem for people from
all walks of life
It knows no racial, ethnic, social or economic
barriers
National Council of Alcohol and Drug Dependency
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IN HIS IMAGE
Abstinence
HOW
AFFECTS YOUR BODY
A L C O H O L
NERVOUS SYSTEM
Irreparable damage to nerve cells (Some die,
other are altered)

• BRAIN DISORDERS -- Alcohol induced dementia
  (Wernicke-Korsakoff syndrome) Cerebella
  atrophy
• PERIPHERAL NEUROPATHY

CARDIOVASCULAR SYSTEM
Increased risk of hypertension, stroke,
cardiomiopathy, heart arrhythmias, congestive
heart failure
LUNGS
Depresses respiratory functions
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IN HIS IMAGE
Abstinence
HOW
AFFECTS YOUR BODY
A L C O H O L
DIGESTIVE SYSTEM
Gastric or duodenal ulcer, esophageal varices,
pancreatitis, gastric cancer Liver because the
liver must filter alcohol from the blood, the
alcohol affects it more than any other organ of
your body.

• excess calories in the alcohol are stored as fat
  in the liver
• functioning liver cells die from alcoholic
  poisoning
• scar tissue replaces dead cells, causing
  cirrhosis

REPRODUCTIVE SYSTEM
MEN - damages cells in the testes, causing
impotence, sterility, possibly enlarged breasts
WOMEN irregular menstrual cycles,
malfunctioning of the ovaries, birth defects in
infants, fetal alcoholic syndrome (mental
retardation)
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IN HIS IMAGE
Abstinence
HOW
AFFECTS YOUR BODY
A L C O H O L
YOUR IMMUNE SYSTEM
Alcohol weakens the bodys defense against
infection and breast cancer
GENERAL METABOLISM
Vitamins deficiencies, Pernicious anemia,
diabetes mellitus type II, hyperlipidemia,
atherosclerosis
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IN HIS IMAGE
Abstinence
A L C O H O L
The WORLD - most abused drug for all the ages
USA (alarming statistics for teenagers)
of all 12-17 years old 37 currently use
alcohol.
5 millions American teens have serious problems
from alcohol use.
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IN HIS IMAGE
Abstinence
A L C O H O L
AND NUTRITION
ALCOHOL highly refined product but low in
nutrients EMPTY CALORIES
For MEN alcohol accounts for 9 of the calories
in the American Diet (Men overfed but
undernourished)
Young people who grew up in non-alcoholic homes
are less likely to have problems with alcohol
when they reach adulthood. A parents example can
make a big difference.
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IN HIS IMAGE
Abstinence
THE DEADLIEST DRUG IN THE WORLD
TOBACCO

• Produces the strongest addiction
• The withdrawal symptoms are terrible
  (irritability, depressed mood, heart rate,
  increased appetite, insomnia, anxiety)

NICOTINE
NICOTINE CARBON MONOXIDE (CO)

• Produce cardiovascular diseases
• decrease the ability of red blood cells to carry
  oxygen respiratory disease

CARCINOGENIC AGENTS

• ..

• EVERY CIGARETTE SMOKED, TAKES 13 MIN OF THE
  PERSONS LIFE SPAN
• IN THE USA IT KILLS ALMOST A HALF OF MILLION
  PEOPLE PER YEAR
• THE BIGGEST FAVOR PEOPLE CAN DO FOR THEMSELVES
  IT TO STOP THE SMOKING HABIT

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IN HIS IMAGE
Abstinence
CAFFEINE
Caffeine is not some energy form that excites our
nervous system, it simply thwarts one of the main
process by which the nervous system is generally
kept calm.
Caffeine k Acetylcholine, k Dopamine
concentration in the brain. Caffeine m the
concentration of Adenosine in the brain.
Adenosine - brake pedals The harder the cell
works, the more Adenosine is produced. After the
brain in fully active, adenosine works to
gradually quiet the brain back down.
Caffeine Similar structure, but its a smaller
size then adenosine. It binds to Adenosine
receptor and blocks it. Adenosine cant do its
job.
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IN HIS IMAGE
Abstinence
CAFFEINE
The effects on
The nervous system
k Stimulation of the brain Insomnia, Irritability
and nervousness. Chronic fatigue. m Intellectual
performances. m Motor coordination. Aggravation
of anxiety disorders and panic attacks.
The Heart and Blood vessels
Arrhythmia ( Irregular heart beat) Coronary
artery disease (Myocardial infarction, and angina
pectoris) Hypertension Vasoconstriction of the
brains arteries
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IN HIS IMAGE
Abstinence
CAFFEINE
The effects on
The digestive system
Gastro-esophageal reflux (GERD) k Gastric acid
secretions ( Peptic ulcers disease) Gastric,
pancreatic, colon carcinoma
The Reno-urinary system
Irritating effect on the kidneys (diuretic
effect) Bladder Carcinoma k Urinary calcium and
magnesium loss (osteoporosis) In Coca Cola
Caffeine plus phosphoric acid - blocks calcium
absorption.
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IN HIS IMAGE
Abstinence
CAFFEINE
The effects on
The General metabolism

• k Basal metabolic rate (5-25)
• k Homocysteine k Atherogenic effect (k
  atherosclerosis)
• k Blood glucose k Insulin resistance
  Diabetogenic effect.
• k Blood fats (Triglycerides Cholesterol) k
  ASC effect.
• m Iron Absorption ( 50) Tanin compounds (in
  tea) g Anemia.
• Interferes with DNA repair process g Congenital
  defects
• g Carcinogenic effects.
• Crosses the placental barrier g Abortion, fetal
  distress, fetal growth impaired
• Secreted in the breast milk g effect on the
  babys heart rate.

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IN HIS IMAGE
Abstinence
CAFFEINE ?
Where is the
COFFEE / TEA (Caffeine, teophyline,
teobromine) 1 cup drip coffee (145 mg) 1 cup
hot tea (65 mg) 1 cup brewed coffee (115 mg)
Ice tea (360ml) (70 mg) 1 cup instant coffee
(85 mg) Green tea (200ml)(40 mg)
CHOCOLATE (Caffeine, teobromine) Milk
Chocolate (30g) (6mg) Baking Chocolate (30g)
(25mg)
SODAS Mountain Dew (54mg) Pepsi (360ml)
(40mg) Coke Diet Coke (45mg)
MEDICATIONS (1 pill) Headache Excedrin
(65mg) Cold Medication (0-30mg) Weight loss
pill (20-200mg)
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IN HIS IMAGE
Abstinence
Do you still want them?
STIMULATING DRUGS CALMING DRUGS Caffeine Tran
quilizers Tobacco Sedatives Some Diet
pills Alcohol Amphetamines Tobacco
POSITIVE EFFECTS Sense of well
being. Relaxes Decreased Fatigue Relieves
Anxiety Sharpens Mind Falls Sense of
peacefulness NEGATIVE EFFECTS Only
Temporary Effect Temporary Effect Premature aging
Solves no problems Depletes resources Depressio
n Depression
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Every habit that is not fully under your control
is an addiction.
eat study work exercise sleep
intelligently...
Balance your Physical, Mental, Emotional,
Social, and Spiritual life!
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He who will observe simplicity in all his
habits, restricting the appetite and controlling
the passions, may preserve his mental powers
strong, active, and vigorous, quick to perceive
everything which demands thought or action, keen
to discriminate between the holy and the unholy
and ready to engage in every enterprise for the
glory of God and the benefit of humanity EGW
ST, Sept 29, 1881. (2BC 1006.) 2MCP 445.5
Simplicity