Whole Body Scale

1
Whole Body Scale

• Marco Viceconti-How whole body modeling impacts
  research and clinical practice
• Use of modeling to augment clinical approach to
  orthopedic problems
• Use of modeling to assess risk of rupture of
  cerebral aneurisms
• Clinical trials

IMAG
2

• Questions covered a range of topics mechanisms
  to increase patient numbers in specific clinical
  studies
• internal validation of a model provided by
  treatment outcome information, differences
  between problem solving and validation
• Model details, how far down in scale do you go

IMAG
3

• discussion of hybrid modeling-use of
  biomechanical and biological models
• Yoram Vodovotz-Translational systems biology of
  inflammation
• Discussed discontinuous process of moving from
  mechanistic studies to health care delivery-value
  of simulations at each level including individual
  patients responses

IMAG
4

• Success stories of modeling at preclinical and
  clinical levels
• Use of models to predict age-related sensitivity
  of cellular elements of the immune system to
  challengebenefit of anti-TNF treatment in sepsis
• Discussion centered on issues related to
  commercialization of models, placing models in
  the public domain and standards for doing so

IMAG
5

• Additional discussion on the role of modeling
  in clinical interventions and clinical trial
  design
• Best model is one that has not yet been
  falsified
• Sharing of models

IMAG
6

• Don Bolser-A skeptics view of modeling
• Role of modeling in neurogenesis of airway
  protection-perception of modeling complex systems
• Moving from skeptic to proponent is enhanced by
  experience with manipulation and simulation of
  the model

IMAG