By: Kim Mendez

1
By Kim Mendez
2

• The first picture taken of Ebola
• 1976, under a scanning electron micrograph
• Classified as Filoviridae
• There are four strains of Ebola Ebola Sudan,
  Ebola Zaire, Ebola Reston, Ebola Tai (Ivory
  Coast)

3
How Ebola is Contracted
4
Signs and symptoms

• Early symptoms Malaise fatigue, fever, low back
  ache, N, V, D
• Late symptoms Conjunctivitis, hemorrhagic rash,
  genital edema, bleeding from E, E, N, Tthen DEATH

5
Hemorrhagic Rash
6
Species Jump
It can jump from monkey to human by the
consumption of bush meat
7
Negative-stranded RNA
8
Filoviridae on cell surface
Elongated and narrow appearance (unlike most
viruses which are bumpy and round)
9
Elongated U or b shape
10
Protein Map
11
First Recorded Outbreak of Ebola

• A small village (Yambuku) in Northern Zaire,
  Africa

12
Areas of recent outbreaks, Zaire, Sudan, Gabon,
Nigeria, Liberia, Cameroon, Ivory Coast, and
Kenya
Legend Villages in the countries
13
1995 Outbreak!!

• Alice, TX 2 Cynomolgus monkeys imported from the
  Philippines are discovered to contain the deadly
  virus.

14
Ribavirin
Treatment...antiviral drug, supportive therapy,
and rehydration
15
C Y A N O V I R I N
Crystal Structure
Extracted from blue-green algae
16
cDNA

• Reverse genetics.. isolating RNA from Ebola

17
Lab Accidents

• Most recent lab accident was in Russia (May 2004)

18
African Ebola Awareness Poster
19
References

• Health.allrefer.com
• Barrientos LG, OKeefe BR, Bray M, Sanchez A,
  Gronenborn AM, Boyd MR. (2003) Cyanovirin-N binds
  to the viral surface glycoprotein GP 1,2 and
  inhibits infectivity of Ebola virus. Antiviral
  Research 2003.
• Center for Disease Control. (2002) Ebola
  Hemorrhagic Fever. http//www.mindspring.com/cinq
  ue/ebola.html
• Scanning electron micrograph of Ebola
  virus-infected cell showing numerous virions
  (arrow) on the cell surface. C.S. Goldsmith and
  J. Carr. From A. Sanchez, A.S. Kahn, S.R. Zaki,
  G.J. Nabel, T.G. Ksiazek, C.J. Peters, in Fields
  VIROLOGY, Fourth Edition, 2001
• http//www.bio.davidson.edu/Courses/Immunology/Stu
  dents/Spring2003/Austin/Immune-2.html
• http//www.vetmed.wisc.edu/pbs/kawaoka/research.ht
  ml
•  http//images.google.com/imgres?imgurlhttp//www
  .ccds.charlotte.nc.us/History/images/ebopsterjpg.j
  pgimgrefurlhttp//www.ccds.charlotte.nc.us/Histo
  ry/Africa/04/burton/burton.htmh225w150sz10t
  bnid9txwBGWfTycJtbnh102tbnw68start174prev
  /images3Fq3DEbola2BVirus26start3D16026hl3D
  en26lr3D26ie3DUTF-826sa3DN

20
(No Transcript)