Use of antibiotics

1
Use of antibiotics
2

• Indications for use

3

• Where is the focus of infection ?
• Clinical assessment
• Gram stain cultures

4

• Initial antibiotic selection depends on
• focus of infection
• gram stain
• patients age
• epidemiological setting
• prior culture data

5

• What is the commonest cause of
• urinary tract infection
• cellulitis
• billiary infection
• meningitis
• septic arthritis
• nosocomial pneumonia

6

• After 48 hours check culture results
• gt Narrow antibiotic coverage
• gtInfection vs colonization

7

• Antibiotic selection depends on
  
• focus of infection
• culture results
• patient age
• tissue penetration
• epidemiological setting
• bactericidal vs static
• renal disease
• liver disease
• pregnancy lactation

8

• Antibiotics excreted mainly by kidney
• Antibiotics excreted mainly by liver
  
  
• Antibiotics safe in pregnancy
  

9

• Dosing of antibiotics depends on
• MIC
• half life of drug
• patient factors

10

• Duration of therapy

11

• Antibiotic combinations
• indications
• disadvantages

12

• Failure of therapy