THE DIFFERENCE

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THE DIFFERENCE
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Industry moves to regulate the term Metal Amino
Acid Chelate

• The NNFA Definition
• Metal Amino Acid Chelate is the product
  resulting from the reaction of a metal ion from a
  soluble metal salt with amino acids with a mole
  ratio of one mole of metal to one to three
  (preferably two) moles of amino acids to form
  coordinate covalent bonds. The average molecular
  weight of the hydrolyzed amino acids must be
  about 150 AMU (Atomic Mass Units) and the
  resulting chelate must not exceed 800 AMU. The
  minimum elemental metal content must be declared.
  It will be declared as a METAL amino acid
  chelate e.g. Copper Amino Acid Chelate.
• Adopted by the NNFA Board of Directors July
  1996
• NNFA Today, Pg . 15, Aug 1996

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What is an Amino Acid Chelate?

• Chelation occurs when a cation (M in the
  figure) is held by ionic and coordinate covalent
  bonds from the same molecule (ligand). The
  ligand backbone isolates the cation from
  reactions with other compounds. Two amino acids
  can chelate a single polyvalent cation resulting
  in a bicyclic, dipeptide-like structure which
  resists gastric acid hydrolysis and intestinal
  enzyme cleavage. The metals in these chelates
  are typically absorbed by active transport at
  jejunal dipeptide absorption sites. When such a
  chelate is ingested, intestinal uptake is
  significantly greater than for corresponding
  amounts of ingested inorganic metal salts.

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Kosher Certified

• All Albion material has been certified as
  Kosher parve by KOF-K.

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GMO Free Statement
Genetic modification is not part of the process
Albion Advanced Nutrition uses to manufacture its
mineral products. Certain finished products may
contain small amounts of formulation aids
comprised of materials derived from corn.
However, such formulation aids do not contain any
intact proteins or DNA. Consequently, Albion
products either 1) have no GMO content or 2)
lack sufficient genetic material to determine GMO
content using currently accepted GMO testing
procedures. January 23, 2002
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• Albion Advanced Nutrition, a leader in
  mineral amino acid chelate production, is pleased
  to announce Good Manufacturing Practices (GMP)
  Registration through the NSF Internationals
  Dietary Supplement Certification Program. Albion
  Advanced Nutrition successfully met all
  requirements included in NSFs GMP Registration
  Program. For almost 50 years, Albion Advanced
  Nutrition has been the leading producer of
  totally reacted mineral amino acid chelates.
  Albion Advanced Nutrition is a leading provider
  of these unique mineral forms, along with mineral
  premixes, granulations, and contract specialty
  minerals.
• GMPs are regulatory requirements that
  provide guidelines for necessary processes,
  procedures and documentation to assure the
  product produced has the identity, strength,
  composition, quality and purity it is represented
  to process. NSF conducted a plant audit to
  verify compliance with the GMPs and will conduct
  periodic audits at Albion Advanced Nutrition to
  ensure continued conformance. GMPs for the
  current NSF Dietary Supplement Program are
  included in the NSF American National Standard
  173-Dietary Supplements, the only American
  National Standard for Dietary Supplements.
• Albion Advanced Nutritions GMP
  registration reflects their continued commitment
  to ensuring quality and satisfaction and gives
  companies confidence that our organization
  operates in conformance to established GMPs. For
  meeting GMP requirements, Albion Advanced
  Nutrition receives a NSF GMP Registration
  Certificate and is listed as such on the NSF
  website (www.nsf.org).
• Albion Advanced Nutrition feels that
  the NSF GMPs Certification is a significant
  validation to the overall goals of our
  manufacturing providing consistent and
  validated mineral forms that are safe and
  effective. NSFs history in the area of Public
  Health and Safety is what lead us to working with
  NSF International in this pro-consumer effort.
• NSF International, an independent,
  not-for-profit organization, helps protect you by
  certifying products and ingredients, while
  writing standards for water, food, air, and other
  consumer goods. Founded in 1944, NSF is
  committed to protecting public health and safety
  around the world. NSF collaborates with the
  World Health Organization Collaborating Center
  for Food and Water Safety and Indoor Environment.
  Additional services include safety audits for
  the food and water industries, management systems
  registrations delivered through the NSF
  International Strategic Registrations, Ltd.,
  organic certification provided by Quality
  Assurance International and education through the
  NSF Center for Public Health Education.

March 8, 2005, Human Products Division
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Quantification of Chelation

• For the first time ever, Albion has
  developed and has had been accepted by the AOAC
  (Association of Analytical Chemists) a test that
  verifies, not only the presence of mineral amino
  acid chelate, but can quantify the percent of the
  ingredient that is a true mineral amino acid
  chelate. The science behind this testing will
  allow manufacturers and marketers of products
  containing mineral amino acid chelates to test
  ingredients that claim to be mineral amino acid
  chelates, and determine whether, in fact, they
  have a chelate, and the percentage of the mineral
  that is actually chelated. The fact that the AOAC
  has accepted this procedure for presentation at
  its annual meeting, this September in St. Louis
  is a true breakthrough. It is the first time that
  a scientific organization has accepted a
  procedure for this purpose Ever!
• Albion Advanced Nutrition believes that
  this will be an industry-changing occurrence.
• September, 2004

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Here are a few things that make Albions mineral
chelates stand out

• Albion possesses over 100 patents in the field of
  mineral technology.
• Only Albion mineral amino acid chelates have been
  given CAS Registry Numbers.
• Only Albion mineral amino acid chelates are
  Kosher Parve.
• Albion metal amino acid chelates have been
  chemically validated, and consequently, are the
  only known chelates that meet the NNFA
  definition.
• Virtually all published research on metal amino
  acid chelates has been done using Albion metal
  amino acid chelates.
• GMO free
• They are hypoallergenic and vegetarian friendly

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What Makes Albion Chelates So Effective? They
are nutritionally functional!

• A nutritionally functional chelate, in
  addition to meeting the basic chelate
  requirements, must
• Have a molecular weight under 800 daltons -
  proper size.
• Be electrically neutral, non-ionizing, and less
  reactive.
• Have proper stability constant stays intact in
  the absorptive gut area.
• Have an easy to metabolize ligand better
  nutrient density.

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Amino Acid Chelate Molecule
Mineral
Amino Acid Ring
Amino Acid Ring
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A comparison of mineral nutrients

• There are so many sources of minerals to
  choose from amino acid chelates, sulfates,
  carbonates, picolinoates, Krebs cycle, rice bran
  chelates. . .How do you know which mineral is
  best?

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Calcium Absorption
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Effects of Manganese Amino Acid Chelate on
lymphocite MnSOD activity
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Changes in erythrocytes Cu-Zn SOD activity
following copper supplementation
b
c
a
a Plt0.001 Significant difference from controls b
Plt0.05 Significant difference from
puresuplementation c Significant increase from
presupplemented arthritics (Plt0.001)
DiSilvestro, et al., J Am Coll Nutr 11117, 1992.
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Mean 51 Cr absorption into rat blood from
Cr(III) chloride, Cr picolinate, Cr
polynicontinate, and Cr nicotaniamide glycinate
chelate
Ashmead S, Proc Int. Conf on Human Nutr, Salt
Lake City, Jan 1995.
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LD-50 studies comparing mineral salts to Albion
Amino Acid Chelates
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Mineral interactions
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How does one evaluate Albion chelates against
other mineral forms in the marketplace which also
talks of availability?

• Simply ask the following questions

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• Are the minerals truly chelated to amino acids or
  just complexed by mixing trace minerals with
  protein?

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• Does the product have stability when subjected to
  various pH ranges found in digestion (2.0 7.5)?

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• Is the mineral product small enough in size
  allowing unhindered movement through the
  intestinal wall?

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• Does the product have test data to show it really
  works?

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• Is it expensive?

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Bottom line

• Albion mineral amino acid chelates are
• Most bioavailable
• Easy to tolerate
• Safe
• 100 in nutrient density
• Superior in physiological activity
• Non-interactive
• Of proper stability constant