Rudy%20Dekeyser

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Rudy Dekeyser 21/04/05
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• origin of the species
• mission objectives
• creating an innovative environment
• is basic high quality research compatible with
  tech transfer?

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• origin of the species
• mission objectives
• creating an innovative environment
• is basic high quality research compatible with
  tech transfer?

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Origin of the species
Antwerp
Diepenbeek
Ghent
Louvain
Brussels
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Origin of the species

• Step 1. Flemish government evaluates the
  life sciences research 1994

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Origin of the species

• The 1994 conclusions
• big names in science

• but lack of
• structural support
• critical mass
• translation in industrial activities

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Origin of the species
The conventional approach

• Dedicate a certain volume of an existing granting
  body to life sciences research

• danger
• slice it thin
• lack of sustainability

• Establish a novel independent research
  institution
• danger
• disturb the equilibrium
• lag phase

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Origin of the species

• Step 2. The VIB concept
• unite existing quality
• build synergy and critical mass
• research
• tech transfer

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Origin of the species

• VIB unite existing quality
• 60 biotech teams in 5 universities

evaluation
select 9 excellent teams
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Origin of the species
U1
U3
U2
VIB vzw
U4
U5
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Origin of the species

• VIB create critical mass
• Flemish government invests
• 5y x 25M 125.000.000
• doubling research budget overnight
• creating critical mass

• Framework agreement
• long term commitment
• in depth evaluation every 5 year

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Origin of the species

• VIB create synergy
• Framework agreement with universities
• key output scientific publications

www.nature.com/reviews/genetics 752 / October
2004 / volume 5
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Origin of the species

• VIB create synergy
• Framework agreement with universities
• tech transfer
• IPR
• joint ownership
• management VIB
• costs VIB
• marketing/exploitation VIB

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Origin of the species

• VIB create synergy
• Framework agreement with universities
• tech transfer - return

patent cost
inventors
VIB
50 VIB
50 univ
40
40
10
10
Department
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Origin of the species

• VIB create synergy
• Framework agreement with universities
• tech transfer return
• UNIV 10 40 40 90
• VIB 10 40 40 90

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Origin of the species

• VIB key facts figures
• foundation 1996
• legal entity not-for-profit
• field life sciences
• budget 2004 60 mio
• headcount 850

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• origin of the species
• mission objectives
• creating an innovative environment
• is basic high quality research compatible with
  tech transfer?

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Mission

• Molecular sciences to improve the quality of life

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Objectives

• conduct frontline basic research
• translate inventions into products for the
  benefit of society
• inform the public

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• origin of the species
• mission objectives
• creating an innovative environment
• is basic high quality research compatible with
  tech transfer?

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VIB - Research

• Major fields
• Oncology
• Cardiovascular/angiogenesis
• Neurobiology
• Inflammation/immunology
• Developmental biology
• Plant system biology
• Microbiology

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VIB - Research
TNF
membrane
TNF-R55
TNF-R75
TRADD
Ub
IKK?
TRAF2
RIP
FADD
Ub
Ub
IKK?/ ?
IKK ?/?
casp8
P
P
MAP3K
P
Ub
apoptosis
P
P
P
I?B
I?B
p50
p65
p65
p50
nucleus
NF-?B dependent genes
inflammation
p50
p65
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VIB - Research
Novel treatment for IBD in clinical trial
Recombinant L.lactis, expressing IL-10
Colitis ulcerosa
Crohns disease
healthy colon
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VIB - Research
VEGF promoter polymorphisms reduce VEGF expression
VEGF d/d mice show adult onset ALS phenotype
Reduced levels of VEGF increase the risk for ALS
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VIB - ResearchQuantitative N-teromics
Ex. Heatmap of ratios of amino-terminal peptides
for 700 IDs from T-Lymphocyte
According to reverse phase chromatography position
According to ratio (O18/O16)
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VIB - Research
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VIB Tech Transfer

• Tech Transfer Technology Transfer
• Knowledge Transfer

the movement of knowledge between different
parties
the transfer of knowledge from an academic
institution to industry
patenting, licensing and establishing start-ups
mining of knowledge gt optimize knowledge
creation
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VIB - Research

• Target frontline
• Create the environment

• excellence bonus
• recruit internationally

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VIB Research international recognition

• internationalisation

• 39 nationalities
• 58 European countries
• 23 Asia
• 11 NS America
• 6,5 Africa
• 1 Australia

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VIB - Research

• Target frontline
• Create the environment

• recognise excellence

• up to date infrastructure

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UGent-VIB research building
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VIB - Research

• Target frontline
• Create the environment

• recognise excellence

• up to date infrastructure

• access to advanced technology platforms

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VIB microarray facility
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VIB proteomics core facility
(Source PhD thesis Kris Gevaert, 2000)
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VIB Genetic Service Facility

• sequencing
• STR-genotyping
• SNP discovery
• SNP analysis

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VIB technology model organisms
drosophila
zebrafish
xenopus
mouse
arabidopsis
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VIB technologies
Bio-informatics
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VIB - Research

• Target frontline
• Create the environment

• Stimulate debate and interaction
• GLC
• VIB seminar
• VIB newsletter
• science clubs
• PhD program

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VIB - Research

• Quality assurance
• IAB

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Institutional Advisory Board 2004
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VIB - Research

• Quality assurance
• IAB

• SAB
• strategic plan
• organigram critical density

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VIB - Research
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VIB - Research

• Quality assurance
• IAB
• SAB
• strategic plan
• organigram
• performance criteria

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VIB - Research

• Performance criteria
• scientifically
• 45 publications in IF gt 10 journals
• 125 publications in IF gt 5 journals

• education
• 35 PhDs

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VIB - Research
IF gt 10
IF gt 5
X 3.3
X 2.7
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VIB Tech Transfer
research
agreements existing companies
records of invention
IPR
start-ups

• facilitate the commercialisation of research
  results for the benefit of society
• promote economic growth
• job creation
• generate research to dept.

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VIB Tech Transfer

• Disclosure and recording of inventions
• Policy
• adapt to academic environment
• pro-active
• minimize administrative hurdles
• treat with priority

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VIB - Tech Transfer
Inventions
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VIB - Tech Transfer
ROI-benchmark
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VIB - Tech Transfer
patent applications
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VIB - Tech Transfer

• Patent applications (PA)
• VIB 48 ROI gt PA
• Benchmark 50 ROI gt PA

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VIB Tech Transfer
portfolio management
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VIB Tech Transfer
Budgets/year - cumulative
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VIB - Tech Transfer
Licensing/RD some collaborators

• Pfizer
• Novartis
• Johnson Johnson
• Solvay
• Abbott
• Bayer

• Innogenetics
• Tibotec
• Galapagos
• CropDesign
• Ablynx
• Tigenix

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VIB - Tech Transfer
Start-up basic principles
VIB operates in a very hands-on manner by playing
the role of seed financier

• conceptualize and write business plan
• strengthen the technology/product base via
  inlicensing
• assist in bringing the team in place
• road show to raise venture money
• assist in the due diligence process

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VIB - Tech Transfer
Start-up case study - nanobody

• Broad application spectrum
• diagnostics/proteomics
• therapeutics
• immuno-affinity
• feed/food

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VIB - Tech Transfer
Start-up case study nanobody

• Technology building
• secured access to 3 basic patents covering
  product claims and production methodology (VUB)
• filed 6 more patent families
• gt 40 patent applications and patents

• (2) Strategic investments
• VIB grant complemented with
• tech transfer project
• IWT grant

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VIB - Tech Transfer
Start-up case study nanobody
(3) Business plan (Ablynx)
(4) Attract lead investor (GIMV)
(5) Establish legal entity (VIB GIMV)
(6) Attract CEO (M. Vaeck, ex-COO Ceres)
(7) Ad interim management

• recruit first employees
• rent lab space
• furnish labs
• establish contacts with potential licensees

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Ablynx nv

• Biopharma
• Foundation 2001
• Location Ghent
• CEO Dr. Mark Vaeck
• Venture Capital 1st round 5 M
• Investors GIMV, BFV, Sofinnova, Gilde

• Venture Capital 2nd round 25 M
• New investors Abingworth, Alta Partners

• Employees 40

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Devgen nv
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CropDesign nv

• Agbio
• Foundation 1998
• Location Ghent
• CEO Dr. Johan Cardoen
• Venture Capital 1st round 11 M USD
• Investors 1st round GIMV, Atlas Venture,
  Sofinnova, BFF

• Venture Capital 2nd round 25.6 M
• New Investors Gilde, ING, DV, Burrill Agbio,
  KBC,
• Technolife 2010

• Venture Capital 3th round 16 M

• Employees 70

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Peakadilly nv

• Biopharma
• Foundation 2004
• Location Ghent
• CEO Koen Kas
• Capital 1st round VIB
• Income 3 mio
• Employees 10

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Tech Transfer - 2004
Start-ups employees
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VIB start-up

• Benefit for society
• multiple therapeutics under development
• novel agronomically improved crop varieties
  under deveopment

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VIB - Tech Transfer
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Ghent Technology Park
DeVGen
Innogenetics
VIB Bio-incubator 2
DeVGen
VIB Bio-incubator 1
Bayer Bio Science
research facilities University of Ghent/VIB
Innovation Incubation centre 2 (University of
Ghent)
Innovation Incubation centre 1 (University of
Gent)
Crop Design
Service Center for biotech
Buildings planned or under construction
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Conclusion

• scientific output and quality improved
  significantly

• tech transfer output has increased from almost
  zero to significant

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• origin of the species
• mission objectives
• creating an innovative environment
• is basic high quality research compatible with
  tech transfer?

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Balancing science Tech Transfer
Groups with collaboration
Groups without collaboration
Yearly avg pubs
science technology
basic applied
Source K. Debackere et al., in prep.
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Balancing science Tech Transfer
Table 1a average number of SCIE publications (1998-2000) Table 1a average number of SCIE publications (1998-2000) Table 1a average number of SCIE publications (1998-2000)
Inventors Non-inventors
Complete sample 35,8 11,7
Sample without outliers ( pubs lt 90) 22,8 12,1
Source K. Debackere et al., in prep.
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Balancing science Tech Transfer

• Conclusion
• High quality basic science tech transfer are
  compatible