Title: Model for Improvement
1Model for Improvement
- Kevin Little, Ph.D., IHI
- Corinna Nyquist, RN, BSN, Indian Health Council
- Marni Kopenski, NP, Gerald Ignace Indian Health
Center - Jana Towne, RN, BSN, Whiteriver Service Unit
2Overview of the Model for Improvement
Kevin Little, IHI 25 June 2008
Based on a presentation developed by Jerry
Langley, IHI Cindy Hupke, IHI for Innovations in
Planned Care for the Indian Health System
2
3Agenda
- Context for IPC work
- Team example 1
- Theory and Concepts-1
- Team example 2
- Theory and Concepts-2
- Team example 3
- Q and A/Discussion
- Next Steps/Summary
3
4Blood Pressure PDSAPurpose/Objective of
CycleTo determine/assess our blood pressure
techniques
- Corinna Nyquist
- Indian Health Council
5PLAN
- The Change
- What are we testing? Taking blood pressures
after a client has rested for 5 minutes vs. upon
entry to clinic. - Who are testing on? The next 5 clients.
- When are we testing? Today.
- Where are we testing? In the medical clinic.
- Our Prediction
- We anticipate that BPs taken 5 minutes after the
client has rested will be better than those taken
when clients first arrive.
6PLAN cont.
- Data
- What data do we need to collect? BPs upon entry
into the clinic and again 5 minutes after the
client is roomed. - Who will collect the data? The team.
- When will the data be collected? Today at 3 pm.
- Where will the data be collected? In the medical
clinic.
7DO (carry out the test)
- What was actually tested? Took BPs on 4 clients
upon entering the clinic and repeated 5 minutes
later after client had been sitting down. - What happened? 4 out of 4 BPs were lower after
resting for 5 minutes. - Observations? BPs decreased when clients were
sedentary for 5 minutes. - Problems? Asked data entry staff what they do if
there are 2 BPs response was that they enter
1st BP taken.
8STUDY
- Blood pressures taken after client was seated for
5 minutes were substantially lower than those
taken upon entry to the clinic. Team realized
that we needed to change our current process and
complete BPs after client is roomed and has
rested.
9ACT
- What changes should we make before the next test
cycle? Meet with MAs and nurses tomorrow
morning and ask them to room the client and then
complete any questionnaires and screens prior to
doing vitals. Also, we need to write protocol
for data entry regarding two results for any
given test. - When will the next test cycle be? Tomorrow.
- Are we ready to implement the change? Yes by
11-13-07.
10Your Observations
- Opportunities to do better?
11Theory and Concepts-1
12To Be Successful at Improvement You Need the
Following
- Will - for improvement
- Ideas - for changes that will lead to improvement
- Execution a framework for action to adapt the
changes to achieve improvement
13Model for Improvement
What are we trying to
accomplish?
How will we know that a
change is an improvement?
What change can we make that
will result in improvement?
G. Langley et al. (1996), The Improvement Guide
A Practical Approach to Enhancing Organizational
Performance, Jossey-Bass Publishers, San
Francisco.
14Fundamental Questions for Improvement
- What are we trying to accomplish?
-
- How will we know that a change is an improvement?
- What changes can we make that will result in an
improvement?
15Model for Improvement
What are we trying to
accomplish?
How will we know that a
change is an improvement?
What change can we make that
will result in improvement?
16An Aim Statement
- Whiteriver Service Unit seeks to fundamentally
redesign its delivery of care for all patients in
order to promote the health and wellness of the
community, and to improve the prevention and
treatment of chronic conditions. We will improve
health care processes and outcomes for each
patient across the entire population in a cost
effective manner. This commitment is reflected
in our strategic goal to provide compassionate,
quality health care that is timely and effective,
that maximizes patient safety and that excels at
best practices.
17Some Guidance to Support the Aim
- We will actively partner with the White Mountain
Apache community to collaborate in the design of
patient-centered care processes in order to have
the community take ownership of the changes. - The initiative will develop care processes which
focus on a positive patient and family members
health care experience. - These processes will be developed, tested, and
packaged in such a manner that they can be spread
throughout Whiteriver Hospital and Cibecue Health
Center within the next 3 years. - The team will define patient care process through
the use of flowcharts create a list of possible
changes, and prioritize and implement the
changes. A specific focus will address how to
sustain improvements. - The initial microsystem that will receive
improvement focus is located in Whiteriver
Hospitals Outpatient Clinic A. Core staff for
the care team will include at a minimum, 1.0FTE
Med Staff coverage (2 physicians and 2 physician
assistants,) 2 RNs, 2 Certified Nursing
Assistants, Medical Clerk, Pharmacist, Dietician,
Lab Tech, Clinical Applications Coordinator and
Patient Registration representative. A patient
panel of 1000 patients who represent all ages
will be created. These patients will participate
as members of their own care teams.
18Some Goals to Support the Aim (within 12
months evaluated annually thereafter)
- Health improvement for this panel of patients (as
measured by chronic condition and preventive
services outcomes) by 100. - Patient and family experience improvement as
evidenced by satisfaction scores to gt 95 and
third next available appointment with the care
team to lt 1 month. - Efficiency improvement as measured by decreased
office visit cycle time to 60 minutes when
pharmacy is included (40 minutes without
pharmacy) and increased value-added face time to
40 min. - Decrease in Urgent Care and Emergency visits by
50 per 1000 patients - Changes will occur within existing funding
resources. - Create a process for identifying waste, and then
reduce it in all forms. - Patients who indicate that they feel confident
managing their own conditions will increase to gt
95.
19Model for Improvement
What are we trying to
accomplish?
How will we know that a
change is an improvement?
What change can we make that
will result in improvement?
20IPC Measures (Fall 2007)
21(No Transcript)
22Intake Screening Bundle
23Model for Improvement
What are we trying to
accomplish?
How will we know that a
change is an improvement?
What change can we make that
will result in improvement?
24Some Change Ideas for IPC
- Empanelling
- Care team
- Use data to drive improvement
- Optimize use of HIT
- Remove waste
- Plan for every pt
- Segment care
- Reminders system
- Move work to appropriate licensure
- Reliable follow-up
- Max packing
- Proactive care across spectrum
- Self-Management
- Integration into community
- BH integrated into primary care
- Train workforce
- Transportation for pts
- Integration of traditional medicine
- Guidelines of care
- Advanced access
- Adjusting meds to control
25Model for Improvement
What are we trying to
accomplish?
How will we know that a
change is an improvement?
What change can we make that
will result in improvement?
26Model for Improvement
What are we trying to
accomplish?
How will we know that a
change is an improvement?
The most effective PDSAs are those that are
linked to your aim, measures, and key change
conceptsthe arrow from the three questions to
the PDSA is not decorative!
What change can we make that
will result in improvement?
27The PDSA Cycle for Learning and Improvement
Act
Plan
- Objective
- Questions and
- predictions (why)
- Plan to carry out
- the cycle (who,
- what, where, when)
- What changes
- are to be made?
- Next cycle?
Study
Do
- Complete the
- analysis of the data
- Compare data to
- predictions
- Summarize what
- was learned
- Carry out the plan
- Document problems
- and unexpected
- observations
- Begin analysis
- of the data
28 The PDSA CycleTestingThe Basics
29Why Test?
- Increase the belief that the change will result
in improvement - Predict how much improvement can be expected from
the change - Learn how to adapt the change to conditions in
the local environment - Evaluate costs and side-effects of the change
- Minimize resistance upon implementation
30Testing on a Small Scale
- Have others that have some knowledgeable about
the change review and comment on its feasibility. - Test the change on the members of the team that
helped developed it before introducing the change
to others. - Incorporate redundancy in the test by making the
change side-by-side with the existing system. - Conduct the test in one facility or office in the
organization, or with one patient. - Conduct the test over a short time period.
- Test the change on a small group of volunteers.
- Develop a plan to simulate the change in some way.
31Do ? Study
- Reasons for failed tests
- 1. Change not executed well
- 2. Support processes inadequate
- 3. Hypothesis/hunch wrong
- - Change executed but did not result in local
improvement - - Local improvement did not impact access or
efficiency -
- Collect data during the Do Phase of the Cycle to
help differentiate the these situations.
32Study ? Act
- Compare data to prediction
- Summarize what was learned
- ACT - Take action on the new knowledge
33The Sequential Nature of PDSA Cycles Building
upon what we learn
- Marni Kopenski
- Gerald Ignace Indian Health Center
34PDSA 5
- Purpose/Objective To determine if patients are
bringing their medications or medication cards to
their appointments (on each appointment card it
says to bring in your medications).
35PLAN
- The Change
- What are we testing? To determine if patients
are bringing in their medication cards or
medications at their visit. - Who are testing on? 5 patients of Marni
Kopenskis (all the diabetic patients on that
day). - When are we testing? June 6, 2007.
- Where are we testing? In the clinic.
- Our Prediction
- We predict that at least 3 of the 5 patients will
bring in either their current med list or the
actual meds.
36PLAN cont.
- Data
- What data do we need to collect? If patient has
a medication list or their meds with them at the
visit. - Who will collect the data? The MA rooming the
patient. - When will the data be collected? Before the
provider enters the room beginning of visit. - Where will the data be collected? On a bright
green recording sheet.
37DO (carry out the test)
- What was actually tested? Measuring the number
of patients who brought in their meds or med
list. - What happened? Of the 5 scheduled diabetic
patients, only 1 patient showed up. - Observations? We didnt realize that we have
many days when scheduled patients dont show up. - Problems? We couldnt accurately tell how many
have a med list or actual meds due to only 1
patient showing up for visit.
38STUDY
- 1 of 5 diabetic patients showed up for their
scheduled appt. That is a 80 no show rate on
that day for diabetic patients. The one patient
that did show up had her medications with her and
a medication card that she carries with her at
all times.
39ACT
- What changes should we make before the next test
cycle? We have to determine our current no show
rate and what we can do to decrease it. Reception
staff has not consistently been calling the day
before to remind patients of appointments. - What will the next test cycle be? On Monday,
June 25, the receptionist will call MKs patients
that are scheduled for Tuesday appointments
will remind them of the appt. date and time, to
bring their meds, and to call and cancel if they
cant make it. - Are we ready to implement the change? Yes
40PDSA 6
- Purpose/Objective Our last PDSA showed we had a
lot of no shows and we wanted to test if calling
patients before their appointments would help
decrease no shows. Our no show rate is currently
18-22 and increases slightly in the summer. Per
reception, they have not been calling patients
because so many phone numbers are inaccurate or
disconnected.
41PLAN
- The Change
- What are we testing? To see if calling the
patients before their appointment helps decrease
no show rate. - Who are testing on? Marni Kopenskis Tuesday
morning patients (9 total) - When are we testing? Reception will call the
patients today (Monday) and chart who shows up
tomorrow. - Where are we testing? In the clinic.
- Our Predictions
- We predict that 1/3 or 3 of the 9 phone
numbers will be accurate, the no show rate will
be less than 18, the patients that reception
actually talked to will show up, and that calling
the patients the day before their appointment
decreases no shows.
42PLAN cont.
- Data
- What data do we need to collect? Call patients
and record if reception - Talked to patient and patient said they would
come to the scheduled appointment - Left a message on a machine or with a family
member - Had a wrong phone number or phone was
disconnected - Didnt get an answer couldnt talk to anyone
- Talked to patient and they rescheduled or
cancelled - On Tuesday, see what patients showed up and if
there is a correlation between calling and
showing up - Who will collect the data? Reception
- When will the data be collected? Tuesday
afternoon after MKs patients have been seen.
43DO (carry out the test)
- What was actually tested? If calling patients to
remind them of their appointments will decrease
no show rate. - What happened? Reception called patients and
were surprised to reach most of them. - Observations? Didnt take long to call patients.
- Problems? We still have some patients without
accurate phone numbers or phones.
44STUDY
- Monday Calling 9 calls made, patients were
reminded of appointments, and encouraged to
cancel if unable to come in. - 1 wrong number
- 2 messages left
- 6 patients were talked to directly and confirmed
their appointments - Tuesday Patients
- 2 people cancelled before their scheduled time
- 5 showed up
- 2 no showed 1 was called day before and said
she would be at appointment. The other no show
had a disconnected phone.
45STUDY cont.
- Only 2 of the 9 patients had a disconnected phone
or wrong number. We had predicted 3/9 so we
overestimated. - No show rate was 22. This was higher than
expected but in normal range. We really thought
this would be lower with the phone calls the
night before. - 6 patients were actually talked to and 5 of the 6
showed up. Therefore, 83 of the people called
did show up for their appointments. - Overall, we feel that the night before phone
calls were helpful patients that cancelled
actually called before their appointment time.
46ACT
- What changes should we make before the next test
cycle? We have now implemented calling patients
the night before their appointments to remind
them. Some staff think we have more disconnected
phones or wrong numbers than these results
indicate. They believe that when we ask patients
to update the registration form, they just say,
its all the same to get back into the clinic
faster. - What will the next test cycle be? For patients
that come in tomorrow, Wednesday, June 27th, each
one will be given a slip of paper to update their
address and phone number in the room while
waiting for the provider. At the end of the day,
reception will compare what the patient filled
out to the chart to find the number of
discrepancies. - Are we ready to implement the change? Yes
47PDSA 7
- Purpose/Objective To determine if we give
patients a piece of paper to fill out address and
phone number while they are waiting in the exam
room, we will find discrepancies with the
information in the chart. - Background We have found that if we call
patients the night before, they show up for their
appointments. However, weve had a difficult time
ensuring we have the correct phone number and
address. Although we ask patients to update their
information at check in, this doesnt always
happen. The last PDSA showed that 22 of patient
had an incorrect phone number.
48PLAN
- The Change
- What are we testing? The match between address
and phone in chart vs. what patients put on piece
of paper. - Who are testing on? Marni Kopenskis patients.
- When are we testing? Wednesday, June 27.
- Where are we testing? In the clinic.
- Our Prediction
- We predict that 25 of patients will say
their information is correct/no changes and when
we compare slip to chart, there will be a
discrepancy.
49PLAN cont.
- Data
- What data do we need to collect? Ask patients if
address or phone has changed since we saw them
last and have them fill out slip of paper while
waiting in exam room. - Who will collect the data? Reception will ask
about any changes RNs will hand out and collect
slip of paper reception will compare with chart.
- When will the data be collected? On June 27th
after patients are gone. - Where will the data be collected? In clinic by
RNs and reception.
50DO (carry out the test)
- What was actually tested? The accuracy of the
information in our charts as compared to what
patients filled out on slip of paper. - What happened? Reception did not ask if there
was an address or phone number change before
handing out slips (every patient got one). - Problems? Reception stated they were too busy to
ask about changes before handing patients the
slips.
51STUDY
- 11 of 17 scheduled patients showed up for their
appointments and it was found that 8 of the 11
did not have discrepancies between the
information they provided on the slip and what
was in the chart. 3 patients did have a change
(and these were the 3 we were not able to reach
the night before). We were close to our
prediction of 25 discrepancy rate and feel this
is pretty accurate.
52ACT
- What changes should we make before the next test
cycle? If we cant reach a patient to confirm
their appointment, they will be given a sheet to
fill out their updated information when they come
in the next day. - What will the next test cycle be? We will retest
with the receptionist just handing out the slips
to the patients who we are unable to reach the
night before. If anyone else in the clinic learns
of a change in information, they will have access
to the slips and can give them to the patient
(the slips will be in the exam rooms). - Are we ready to implement the change? Yes
53Your Observations
- Opportunities to do better?
54Theory and Concepts-2
55Repeated Use of the Cycle
Changes That Result in Improvement
DATA
Hunches Theories Ideas
56Repeated Use of the Cycle
Changes That Result in Improvement
DATA
Implementation of Change
Wide-Scale Tests of Change
Follow-up Tests
Hunches Theories Ideas
Very Small Scale Test
56
57Repeated Use of the Cycle
Changes That Result in Improvement After cycles
have demonstrated that the change CAN work, use
more cycles to help you figure out how the change
WILL work, every day
DATA
Hunches Theories Ideas
Investigation
Demonstration
Implementation
58What we mean by implementation
- You know a change has been implemented when you
can have 100 staff turnover in your organization
and the change will remain in place. - Implementation requires that staff and leaders
have built the change into formal plans, job
definitions, training, and intentional reviews.
Implementation typically requires a process
perspective, too.
59Aim Improve primary care appointment
availability through reducing and standardizing
appointment types
Improved access
Cycle 5 Staff education in new
standards
Cycle 4 Standardize appointment types
Cycle 3Test the types with 1-3 physicians
Cycle 2Compare requests to the types for one week
Reduction of appointment types will increase
appointment availability
Cycle 1Define a small number of appointment types
60Overall Aim Increase Access
Specific Test Cycles
Standard panel size
Scheduling protocols
Appointment types
Team approach to care
61Principles of Testing a Change
- 1. Build Knowledge Sequentially
- Test on a small scale
- Use multiple cycles
- 2. Increase the Ability to Predict from the
Results of the Test - Collect data over time during the test
- Test over a wide range of conditions
62Why predict?
- Explicit prediction of outcomes in uncertain
situations followed by comparison of outcomes to
the prediction may enhance our ability to learn.
- This effect has been suggested to occur at the
level of brain chemistry activating dopamine
neurons by uncertainty mobilizes attention,
motivates risk-taking, and promotes learning
about relationships between external stimuli and
consequential events. (Shizgal and
Arvanitogiannis (2003), p. 1858 discussing
Fiorillo et al (2003)) - Forces you to think about test measures
- Can increase staff interest in your tests
63Data for Improvement
- Key measures (to answer question 2)
- Data to support cycles (short term, process
focus, include qualitative) - Implementation relies on a combination of the two
types
64Successful Cycles to Test Changes
- Do not try to get buy-in, consensus, etc.
- Be innovative to make test feasible
- Collect useful data during each test
- Test over a wide range of conditions
- Plan multiple cycles for a test of a change
(think a couple of cycles ahead) - Scale down size of test ( of patients, location)
- Test with volunteers
65Questions for Users of the PDSA Cycle
- Is the planning based on theory? Stated?
- Are the predictions made prior to data
collection? - Are multiple cycles run?
- Is there documentation of what was learned?
- Does the learning provide a basis for action?
66 Example from On-Line Course Accelerating
Learning and Improvement
- What Cycle can we complete by 3 PM?
- Willing to compromise on scope, size, rigor, and
sophistication, but the Cycle must be completed,
recorded, and sent to us by the time that we get
back together at 3 pm ET.
67Documenting Improvements
68Link changes to your measuresAnnotated Time
Series
69Family of Measures for Chronic Care BTS
70Track your PDSA cycles and Key measure(s).
Annotate your graph to reflect whether a change
led to an improvement
NE Team Actual team PDSA cycles and graph
71PDSA WorksheetPlan Do Study Act
- Organization Whiteriver
- Date 11/9/07
- PURPOSE/OBJECTIVE OF CYCLE
- Define patient perception of appointment time
- 4 question survey of Hon-Dah staff regarding
perceptions regarding appt times
72PLAN the change, data collection and predict
- The Change
- What are we testing?
- When do patients think their appt time starts?
Do patients perceive that they should meet with
the provider at their appt time? - Who are we testing the change on?
- 5 Hon-Dah employees Use extremes
- younger, older
- When are we testing?
- November 7
- Where are we testing?
- Hon-Day conference center. And casino ?
73- Predictions
- What do we expect to happen?
- People will say that the visit with the
provider - begins at their appointment time (vs.
the visit process - starting at their appointment time)
- Data
- What data do we need to collect?
- Read questions to them
- If your clinic appointment is at 900, what
do you - expect to happen at 900?
- Who will collect the data?
- Emilia and Cindy
- When will the data be collected?
- This afternoon
- Where will the data be collected?
- In the casino area
74DO Carry out the change/test collect data and
begin analysis
- What was actually tested
- 5 persons who asked their perceptions
- What happened?
- 1 the doctor (shed arrive 5 minutes early)
- 1 doctor
- 1 nurse (vital signs)
- 1 doctor (arrives 20 minutes early to get
everything done and see her doctor at 900) - 1 not to get seen (if I come early I still
wait. I expect that Ill see my doctor at
1000) - Observations
- Can group perceptions into 3 categories doctor,
nurse, no one - 2 said they would come early for appt
- Problems
- No problem with understanding the question.
75STUDY Complete analysis of data, summarize what
was learned, and compare data to predictions
- 60 said they would see the doctor at 900
- 20 said they would see a nurse at 900
- 20 said theyd wait an hour to be seen
- 80 expect to see a care provider at 900
- Majority of peoples perceptions met our
prediction. - If we want to be patient focused, we need to
adapt to their perceptions -
- ACT What changes should we make before the
- next test cycle?
- We know how to ask the question.
- The prediction is good.
- Where test next
- Increase the number of people asked.
- What will the next test cycle be?
- November 8 first thing in the AM for 10
minutes as many as possible. - Are we ready to implement the change?
- NOOOOOOOOOOOOOOOO
76Several cycles later.
77PDSA WorksheetPlan Do Study Act
- Organization Whiteriver
- Date May to June 2008
- PURPOSE/OBJECTIVE OF CYCLE
- Decrease interval between patients appt time and
when provider interaction begins.
78PLAN the change, data collection and predict
- The Change
- What are we testing?
- Moving clinic start times from 820am to 840am
and 1240pm to 100pm. - Who are we testing the change on?
- Clinic staff, providers and empanelled
- patients in IPC clinics.
- When are we testing?
- Beginning with June provider schedule
(5/19- - 6/22).
- Where are we testing?
- Clinic A
79- Predictions
- What do we expect to happen?
- Staff will be more prepared for clinic
day and - patients will be seen nearer to their
actual appt time. - Data
- What data do we need to collect?
- Cycle time data and experiences of staff.
- Who will collect the data?
- Clinic A staff.
- When will the data be collected?
- May 19-June 22, 2008
- Where will the data be collected?
- Clinic A
80DO Carry out the change/test collect data and
begin analysis
- What was actually tested
- Shift of appt day 20 minutes later, from
0820-1040 to 0840-1100 and 1240-1540 to
1300-1600. - (Data reported through end of May only).
- What happened?
- Patients saw their providers nearer to their
actual appt times and overall patient cycle times
decreased. No negative impact was noted on appt
times, staff lunches or when the clinic day ended.
81- Observations
- Staff were very positive about being prepared for
the day, value-added time increased. Staff said
they didnt even notice when asked about impact
to lunch times or the end of the clinic day. The
time between appt and provider interaction has
previously been decreasing with clerks rooming
patients. - Problems
- Staff have become so efficient there is no longer
time for the patient to complete the paper intake
self-screen and staff have reverted to doing this
verbally.
82STUDY Complete analysis of data, summarize what
was learned, and compare data to predictions
- Times from patient arrival to provider decreased
from 46 to 33 minutes - Interval between actual appt time and provider
interaction decreased from 30 to 27 minutes - Overall cycle times decreased by 19 minutes.
- Value-added time increased 6.
- Staff more prepared for clinic day so visits and
day flow more smoothly.
83STUDY Complete analysis of data, summarize what
was learned, and compare data to predictions
- No negative impact to appts, lunches or the end
of the clinic day were noted. - Interval between actual appt time and provider
interaction had been decreasing with testing of
clerks rooming patients. Appt time shift appears
to continue this decrease. - Predictions were supported
84Cycle time impact to patients
85Cycle Time Results-Without Pharmacy visit
86Cycle Time Results-Including Pharmacy visit
87ACT
- What changes should we make before the next test
cycle? - Test cycle needs to be completed as June data
has not been analyzed. - What will the next test cycle be?
- Pending completion of this cycle
- Are we ready to implement the change?
- Pending completion of this cycle
88Your Observations
- Opportunities to do better?
89More Questions and Discussion
90Next Steps
91How could you begin?
- Think about the following
- What are the current results within the IPC-IHC
for your organization? Is there anything that
stands out as needing improvement - Do you have a team already at work? Ask the team
about plans for tests in the coming week or so. - What are some things that you think could go
better in the clinic flow and communication? - What are things that the patients and families
complain about? - What are things that you are doing well, but not
doing reliably or regularly at this time? - Think about timeliness issueshave any?
92Example
- Took a look at the intake screening bundle
results and found that depression screening is
not routinely being done and pulls down the
percentage of screening bundles being completed
in our organization. - Identified the current process
- Nurse identifies current status
- Physician does the screen in the room
- Hunch to test We feel that if the 2-question
screen was done initially by the nurse, followed
up by nurse administered PHQ when warranted, it
will streamline the visit and also increase the
percent of screens being done.
93Another Example
- Physicians are complaining that the review of the
record for current status is taking too long and
delaying the clinic flow. - Hunch If the iCare summary sheet was printed
off by registration, it could be placed on the
chart and sent back to the nurse to verify more
quickly that scanning the chart. - Can you test this without the patients present?
Role play, use each other to test the flow
94One more.
Done without patients present!
95(No Transcript)
96Additional notes on the Model for Improvement
- Model for Improvement analogous to behavior in
other organisms - Behavior analogous to the Model for Improvement
is exhibited by cells swimming in a
mediasomething like the Model for Improvement
appears to have a long evolutionary history! - Â
- a. cells carry out measurements and
record them all the time. The bacterium swimming
upstream in a glucose gradient was my initial
candidate example of an autonomous agent. The
bacterium does so by molecular sensors that
measure glucose, a molecular motor with a stator
and a rotor that can rotate in either direction,
and a flagellum that can rotate in two
directions, causing swimming in one direction
and tumbling in the other. The cell achieves
swimming upstream by continuing to swim if the
glucose concentration is rising and tumbling then
swimming in a random direction if not. Kaufmann
(2000), p. 150 - b. Human sperm act in the same way as the
bacterium. The sperm seek a human egg, navigating
a chemical gradient with measurements made by an
olfactory receptor. - it has been known for some time that
olfactory receptors (ORs) reside in spermatozoa,
the function of these ORs is unknown. Here, we
identified, cloned, and functionally expressed a
previously undescribed human testicular OR,
hOR17-4. hOR17-4 functions in human sperm
chemotaxis and may be a critical component of the
fertilization process. Spehr et al (2003), p.
2054 - Explanation of chemotaxis To
determine the behavioral implications of our
findings, we investigated the effects of
bourgeonal on human sperm swimming. An initial
experiment tested for the accumulation of cells
in microcapillaries placed within ascending,
uniform, or descending chemical gradients.
Results were used to distinguish between
mechanisms of chemotaxis (directed movement with
respect to a chemical concentration gradient),
chemokinesis (change in swim speed), and cell
trapping (arrest of swimming). In both the
ascending and uniform gradients, cell
accumulation within capillaries increased
significantly as a function of dose) two-way
analysis of variance (ANOVA) F4, 281
 30.01, P lt 0.0001. Moreover, densities of
cells in capillaries within an ascending gradient
were significantly higher than those within a
uniform or descending gradient (two-way ANOVA
F2, 281  164.28, P lt 0.0001). Finally, at each
effective concentration (10-8 to 10-5 M),
accumulation of cells in capillaries was ranked
in the following order, according to chemical
gradient ascendinggtgt uniform gt descending. These
collective results are consistent only with a
chemotaxis mechanism--that is, directed movement
toward a region of locally elevated bourgeonal
concentration . (Spehr et al. p. 2057) -
- In the bacterium example, the aim is
food in the sperm example, the aim is an egg.
In each example, there is a need for measurement
and a requirement that the cell can change
direction in response to measured performance.
Then there is a test cycle. We do not claim
there is a conscious plan by the cells, rather
simply that after an action is taken (swimming in
a particular direction), measurements are taken
and compared with desired behavior of the signal
(glucose increasing, buorgeonal increasing), and
change in direction is made if desired behavior
of the signal is not seen. These steps are
clearly analogs of Do, Study and Act.