Coastal IVF

1
Coastal IVF

• Infertility Information and
• Coastal IVF Fertility Services Results
• Click Slide Show button at bottom left to start,
  then right mouse button to change slides

2
Introduction

• The figures given in the following slides are
  drawn from Coastal IVFs patient population over
  a 3 year period (Jan 2005 Dec 2007). The
  results for 2005 and 2006 are drawn from data
  reported to the Australia New Zealand Database
  (ANZARD). Results for 2007 are drawn from our
  clinic data prior to reporting to the ANZARD. The
  results represent 2 groups of patients- firstly
  those undergoing a full ovarian stimulation cycle
  for IVF or ICSI (466 cycles) and secondly those
  undergoing frozen embryo transfers (259 cycles).
• The results can be used as a general guide and
  are given to illustrate the clinical performance
  of our facility within that time frame.
• Due to differences in patient populations between
  ART clinics, the figures are not valid for
  comparing clinics nor should they be interpreted
  as being strictly representative of your specific
  situation. You should consult with Dr. Stokes for
  information relating to your specific situation.

3
Results and Care

• Have you been a patient at a large metropolitan
  clinic?
• Do you feel lost in the crowd ?
• Would you like a more personal approach?
• Large IVF units are unable to match our
  combination of superior results and intensive
  personalized care.
• Compare Coastal IVF directly with the Top
  Quarter of IVF units in Australia in the next
  slide

4
Our Live Birth Rates per started cycle compared
with the top quartile of fertility centres
(Assisted Reproduction Technology in Australia
and New Zealand 2005. First quartile of all
Australia New Zealand IVF units)
5
Causes of Infertility ()
6
Coastal IVF compared to the 2005 National
Average Assisted reproduction technology in
Australia and New Zealand 2005.
7
The effects of female age on success rates

• Success rates need to be interpreted with care.
  The results shown below are overall results for
  all patients passing through our program.
  However, there are factors which have a
  significant affect on the outcome for an
  individual couple. The most important of these is
  the effect of female age. Older (reproductively
  speaking) women tend to have lower success rates
  due to the normal biological changes that occur
  with increasing age. These changes have a
  profound effect on egg quality which in turn
  affects the embryos preventing development beyond
  the early embryo stages. Thus although
  fertilisation and early embryo development may
  occur in the laboratory these "older" embryos
  will have a significantly reduced potential for
  further growth. The results below show our
  clinical pregnancy rates according to female age
  compared to the program results overall and is
  representative of similar data reported worldwide
  on the relationship between female age and
  pregnancy rates . There are many other factors
  which need to be taken into account in
  interpreting results and these are best discussed
  on an individual basis at the time of
  consultation.

8
Embryology outcomes for women lt37 years old (224
oocyte recoveries)

• Average Number of eggs collected 15.7
• Average fertilisation rate after IVF 68.51
• Average fertilisation rate after ICSI 81.72
• Average fertilisation rate after ICSI 64.51
• 1Percentage of collected eggs
• 2 Percentage of injected eggs
• Data from 2005 - 2007

9
Embryology outcomes for women 37 years and
older(202 oocyte recoveries)

• Average Number of eggs collected 9.5
• Average fertilisation rate after IVF 65.11
• Average fertilisation rate after ICSI 77.42
• Average fertilisation rate after ICSI 58.21
• 1Percentage of collected eggs
• 2 Percentage of injected eggs
• Data from 2005 - 2007

10
Womans age and clinical pregnancy rates per
embryo transfer
Data from 2005 2007 ( 375 embryo transfers)
11
Womans age comparison of positive pregnancy
tests and development of foetal hearts after
embryo transfer
Data from 2005 2007 (375 embryo transfers)
12
Frozen embryo transfer - Introduction

• Frozen embryo transfer is a valuable addition to
  the range of assisted reproduction treatments
  which enables the storage of surplus embryos
  generated during a fresh stimulated IVF cycle.
  These embryos can thawed at a later date for
  replacement thus avoiding the repetition of
  another stimulated cycle.
• Results are shown by age group and for all frozen
  embryo transfers for the years 2005 to 2007.

13
Clinical Pregnancy rates using frozen
embryos(2005-2007, 259 embryo transfers)
14
Single embryo transfer

• Multiple pregnancy is an outcome which carries a
  risk of subsequent obstetric complication.
  Multiple pregnancy will result more commonly when
  there is more than one embryo replaced. Recent
  studies both overseas and in Australia have shown
  that in a specific group of good prognosis
  patients single embryo transfer gives only
  slightly reduced pregnancy rates compared with
  double embryo transfers. Coupled with recent
  improvements in embryo freezing and thawing
  methods the prospects for achieving a pregnancy
  using embryos obtained from a single stimulated
  cycle are good, when the use of both fresh and
  frozen embryos is combined. In such cases the
  risk of multiple pregnancy is considerably
  reduced.
• Coastal IVF encourages the use of single embryo
  transfer in appropriate instances.
• The next slide illustrates
• the trend in our clinic from 1998 to 2007 to
  transferring fewer embryos whilst not
  compromising pregnancy rates. The red line
  represents the average number of embryos
  transferred, the dark green bars shows the
  clinical pregnancy rates and the light green bars
  show the multiple pregnancy rates for 546 fresh
  embryo transfers in women lt 37 years old.

15
Number of Embryos transferred (nET), Clinical
Pregnancy and Multiple Pregnancy Rates for fresh
embryo transfers in women lt 37 years old(n 546
embryo transfers)
16

• For further information please refer to our web
  site www.coastalivf.com.au
• Coastal IVF
• Cnr 2nd Ave and Esplanade
• Maroochydore, QLD, 4558
• AUSTRALIA
• Telephone Itnl. 61 7 5443 4301
• Fax Itnl. 61 7 5443 4352
• Bringing someone special into peoples lives