Physical and Biological Determinants

1
PROGRAM Overview
Physical and Biological Determinants For Optimal
PDT
2
Investigators

Hasan Professor NIH RO1 and R44 ONR,
DOE Nishioka Associate Professor DoD ,
Whittaker Maytin Head, Section on Molecular
Dermatology NIH Pogue Assistant Professor
NIH R43, RO1, PO1 Ortel Assistant Professor
Career Dev Awd (DF) , ONR Hamblin Assistant
Professor ONR Redmond Associate Professor NIH
RO1, DoD Wilson Professor NIH PO1, NCIC
3
Investigators

Hasan Professor NIH RO1 and R44 ONR,
DOE Nishioka Associate Professor DoD ,
Whittaker Maytin Head, Section on Molecular
Dermatology NIH Pogue Assistant Professor
NIH R43, RO1, PO1 Ortel Assistant Professor
Career Dev Awd (DF) , ONR Hamblin Assistant
Professor ONR Redmond Associate Professor NIH
RO1, DoD Wilson Professor NIH PO1, NCIC
4
Investigators
Sung Chang, Ph.D. Bin Chen, Ph.D. Sanjay Anand,
Ph.D. Lothar Lilge, Ph.D. Juan Benavides,
M.S. Imran Rizvi, M.S.
Amor Khamencouche, M.D. John Poneros, M.D. David
Forcione, M.D. John Evans, M.D. William
Puricelli, R. N.
5
Projects
Cellular modulation(preclinical and molecular
biology)
Cellular modulation (Barretts)
On line dosimetry
Molecular cellular responses to PDT and
interventions
physics-biology interactions
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Photosensitizers and Biologic Models

• Two program PS, ALA-PpIX and BPD-MA
• -Clinically used and approvedfor non Ca
  indications
• Prostate Cancer Animal models
• 6 models, orthotopic and ectopic, androgen
  responsive and non responsive
• Human Studies
• Psoriasis
• Barretts

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Animal models
R3327G Line (rat PCa)
Orthotopic LNCaP LN mets