MicroNano Systems

1
Micro-Nano Systems
Andrey Sosnov
ChemRar Hi-Tech Center Innovative Life-Science
Cluster
2
Content

• Description of ChemRar
• RD activities
• International Cooperation
• RD in NanoBio

3
Description of ChemRar
ChemRar Hi-Tech Center is non-government
life-science cluster in RF for drug discovery and
development based on advanced technologies.
ChemRar unites several high-tech organizations
working in the field of pharmaceutical research
and development from discovery of new biotargets
and high-throughput screening (HTS) to
development of innovative drug formulations and
drug delivery systems.

• 300 people with strong background
• 17 years in life science RD and services
• RD capabilities in Russia, U.S.A., logistics and
  business centers globally
• Solutions for pre-clinical Drug Discovery
• Chemical Diversity Research Institute (CDRI) is
  core organizations in CHEMRAR Hi-Tech Center.
  CDRI is a CRO specialized in combinatorial,
  medicinal, analytical, computational chemistry,
  and high-throughput screening for early drug
  discovery.

4
RD activities
Expertise offered by ChemRar Hi-Tech Center
organizations

• Virtual (computational) screening of compounds
• Combinatorial synthesis of small-molecule organic
  compounds and generation of combinatorial
  libraries
• The largest bank of drug-like samples in Russia
• Medicinal and agro chemistry
• High-throughput biological screening (HTS) of
  chemical compounds for pharmaceutical,
  agrochemical and biotechnology industries
• Assay development for biological targets
• Early ADME/Tox profiling
• Application of visualization systems in vivo for
  animal tests
• Development of drug delivery systems (from
  systems based on biodegradable polymers to
  nanoparticles (NPs) with tunable pharmacological
  properties)
• Development of innovative drug formulation
  platforms.

5
International Cooperation

• The place of ChemRar Hi-Tech Center and CDRI in
  the
• international drug discovery cooperation

6
RD in NanoBio

• Development of drug delivery (DD) systems
• Non-covalent DD system based on NPs contain Taxol
  and biodegradable polymer
• Non-covalent DD systems based on cyclodextrines
  (in cooperation with ROSC and ORNL US DOE)
• DD systems based on MNPs (in cooperation with
  ROSC and ORNL US DOE)
• Chemistry of nanomolecules
• Liquid-phase and solid-phase synthesis
• Nano-medical chemistry
• Analytical chemistry of nanomolecules
• Bio-screening of nanomolecules and NPs
• Testing of ADME/??? properties of nanomolecules
  and NPs
• Application of visualization systems in vivo for
  investigations and diagnostics

7
Thank you
Welcome to Partnering Cooperation
Andrey V. Sosnov, Ph.D. CDRI Deputy
Director phone [phone] mobile 7(903)
622-2774 fax [phone] sva_at_iihr.ru Andrey
.Sosnov_at_gmail.com Additional information www.che
mrar.ru www.iihr.ru