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First a review

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First a review... Adopt as a perspective that: One B-cell produces one antibody ... First a review... now with images. And, I will use images from a different source. ... – PowerPoint PPT presentation

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Title: First a review


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First a review
  • Adopt as a perspective that
  • One B-cell produces one antibody
  • Make that perspective more exacting
  • One B-cell produces one idiotype.
  • Cassettes (V, J, D,) (aka gene segments) fuse
    (to make an idiotype).
  • Fusing occurs because RAG recognizes one turn/two
    turn signals on cassettes.
  • CDR3 develops through junctional flexibility
    (trimming) and addition of P N nucleotides
    (expanding).
  • CDR1 and CDR2 (especially) and CDR3 become more
    varied because of somatic hypermutation.


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First a review now with images
  • And, I will use images from a different source.
  • Remember to be critical of what interpretative
    drawings convey

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First a review now with images
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First a review still with images
  • RAG what does it do? how does it work?

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First a review still with more images
  • RAG what does it do? how does it work?
  • what about PN nucleotides?

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PART IV (some new stuff)
  • How do immunoglobulins assemble?
  • Some immunoglobulins are in the surface membrane
    of immature B-cells while other immunoglobulins
    of the same idiotype are secreted by mature
    B-cells. Whats the difference?
  • Similarly, identical variable regions can be
    shared among different isotypes. How?
  • B-cells are diploids with two sets of genetic
    instructions. How does just one set get
    expressed?

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How do immunoglobulins assemble?
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Some immunoglobulins are in the surface membrane
of immature B-cells while other immunoglobulins
of the same idiotype are secreted by mature
B-cells. Whats the difference?
10
Similarly, identical variable regions can be
shared among different isotypes. How?
11
B-cells are diploids with two sets of genetic
instructions. How does just one set get
expressed?
12
The general scheme of B-cell development
  • STEM CELL
  • ?
  • pro (genitor) Bcell
  • ?
  • pre Bcell
  • ?
  • Ag-selected (? stimulated)- Bcell
  • ?
  • Ab secreting plasma cell
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