Sensory efficiency

1
(No Transcript)
2
Sensory efficiency activity a model
Yesterday
ADL
Hearing
-.59
.23
Expanded competence
Basic competence
.17
Age
.68
-.78
.42
Vision
3
(No Transcript)
4
(No Transcript)
5
(No Transcript)
6
(No Transcript)
7
White matter loss Age
From Albert and Killiany, 2001
8
(No Transcript)
9
Normal Brain Aging Summary

• Mild atrophy does occur with normal aging
• Mild atrophy affects mostly the frontal and
  temporal areas of the brain
• Structural MRI shows greater white than grey
  matter loss
• Consistent with changes in neuron viability
  rather than with neuron death
• Prime candidate myelin degeneration

10
Gage, FH. Brain, repair yourself. Scientific
American 2003289(3)46-53
11
Neuritic plaque
12
Neurofibrillary tangle
13
Alzheimer disease Ten warning signs

• Memory loss that affects day-to-day function
• Difficulty performing familiar tasks
• Problems with language
• Disorientation of time and place
• Poor or decreased judgment
• Problems with abstract thinking
• Misplacing things
• Changes in mood and behaviour
• Changes in personality
• Loss of initiative

14
Lesson from the Nun Study
MMSE Mini Mental Status Exam NFT
Neurofibrillary tangle NP neuritic plaque DP
diffuse plaque