HunterKiller Peptides: A New Cancer Therapy

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The Buck Institute For Age Research
Extending the healthy years of life
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A Beautiful Mind, Wasted A new look at
Alzheimers disease
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Adults with Dementia by Percent
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Alzheimers Disease--a Century-Old Mystery
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Neuroanatomy 101
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The Hippocampus--Key for Memory!
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Creating Alzheimers in a Mouse--Mouzheimers
Disease
g-secretase cleavage
b-secretase cleavage
26D6
NH2
COOH
The plaques are mainly this!
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Mouzheimers Looks and Acts Like Alzheimers
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But Wait! A New Part of the Story!
g-secretase cleavage
b-secretase cleavage
26D6
NH2
COOH
a-secretase cleavage
A
D664A

• CT15 antibody

KKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
a664 antibody
C31
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Humans have C31--but does it mean anything?
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What happens to Mouzheimers if C31 is prevented?
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There are a quadrillion connections in the
brain! (10 million years to count them all)
a-synaptophysin Propidium iodide
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We can prevent the loss of connections in
Mouzheimers!
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Do the brain connections work? (Think of the
holidays)
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The Mouse That Remembered to Roar Alzheimers
Electrophysiology Normalized by Blocking C31
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Glial scarring also requires C31
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A normal mouse can remember
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Mouzheimers
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Mouzheimers no more
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Mouse Y-maze another way to check memory
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D664A Transgenic Mouse
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Stem cells in the brain
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Screening for Novel Therapeutics
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A New Approach to Treatment?
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So What Does All This Mean?
A New Look at Alzheimers Disease
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Alzheimers Disease The Minority Report
The Dependence Receptor Theory of Alzheimers
Disease
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Alzheimers Disease The Treatment?
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Alzheimers Disease The Minority Report
APP Trophic factor
Target
APP A?
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Dead Neurons SocietyVeronica Galvan Karen
Poksay Vi Nguyen Shahrooz Rabizadeh
Charlotte Egger Ram Rao Susana Castro (U.
Mx.) Joanna Fombonne Alexei Kurakin Veronika
Stoka (now with Prof. V. Turk) Daniel Lu
(UCSF) Takanori Yokota (U. Tokyo Medical)
Patrick Mehlen (now at CNRS) Li-tao Zhong
(Burnham) David Madden Nanette RookeKayvan
Niazi Sylvia ChenOlivia Gorostiza Marina
AtaieCollaborators Patrick Mehlen, Ed Koo,
Lennart Mucke, John Reed, Guy Salvesen, Doug
Green, Michael Hayden, Jamal Nasir Thanks
for support NINDS, NIA, NCI, ABI, Alz. Assoc.,
ISOA, Drown Fdn.
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The Buck Institute For Age Research
Extending the healthy years of life