New PPT Slides for the Mary Crowley

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Scientific and Prevention Advisory Council (SPAC)
Final Report

• Integrated council of 20 cancer health care
  leaders selected from broad areas of expertise
  (patient advocacy, prevention, hospital
  administration, business, science, surgery,
  pediatrics and oncology)
• Located in broad geographic regions of Texas
• Selected by oversight subcommittee of Dr. Joe
  Bailes, Cindy Brinker Simmons and Lionel Sosa

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SPAC Addressed 7 Issues

• Areas of priority
• Areas of research need
• A plan for drug and IP development which will
  expedite commercialization
• A broad representative pool of grant reviewers
• Education programs
• A separate prevention initiative
• Definition of measures of production

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As an overall direction for CPRIT investment
SPAC recommends that CPRIT move beyond (and not
duplicate) current NIH funding approaches and
formulate innovative collaborative relationships
between business, academia, private institutes,
community practice and not for profit centers
within Texas to carry out focused research
directives with immediate or short return to
clinical application.
5
SPAC feels it will be necessary to establish
shared statewide resources such as malignant/non
malignant tissue banks, biomolecular technology
analysis infrastructure, clinical database,
biostatistics/bioinformatics, genomic and
chemical libraries, GMP regulatory/quality
assurance, preclinical, manufacturing and
clinical testing infrastructure necessary to meet
FDA standards for preventive, diagnostic and
clinical product approval.
6
These shared services need to be established in a
way so as to provide, in time, independent
revenues to complement philanthropic and tax
payer support and to maximize the chance for
commercial product development and pharmaceutical
relocation to Texas.
7
Effective communication systems and management
coordination will need to be established enabling
rapid transfer and translation of information to
the investigators, community and CPRIT institute.
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The consensus among SPAC is for a focus involving
the basic cellular, molecular and immunologic
biology of cancer and to translate this into new
methods for prevention, early detection and the
treatment of cancer.
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• Such a focus will allow us to establish a process
  to
• Implement new methods of identifying Texans at
  the highest risk of developing cancer, and to
  communicate preventive cancer measures
• Enable our scientists to be able to construct
  molecular signal maps within cancer and to define
  biorelevant interactions that will allow
  personalized directions for cancer diagnostics
  and therapy
• Not only cure cancer, but where applicable and of
  greater probability, to manage cancer as a
  chronic disease (similar to hypertension and/or
  diabetes) 100 survivability

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