Gap Junction

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Gap Junction
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• Non Synaptic Cell-Cell Junctions
• Intermediate Junction
• Desmosome
• Gap Junction
• Local circuit current
• Depolarization of the adjacent resting cell

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• 20 Angstrom in diameter
• Molecules lt 1000 daltons
• (750 daltons1 angstrom 1.0E-10 meter)
• Low Resistance
• Resistance
• Ca
• pH
• Electric Fields
• Sodium concentration

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• Electrical coupling via gap junctions is
  extremely important in the brain and for
  functioning of the heart (myocardium).
• In nonexcitable cells, such as liver or lens
  cells, gap junctions mediated an exchange of
  metabolites which is vitally important.

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• Results
• Cardiac intracellular space is electrically
  interconnected.
• Activation in one part of tissue continuous
  contiguously to all surrounding tissue.

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Imaging of intracellular transport of
Connexin43-GFP. Connexin-43 travels from the ER
through the Golgi and is targeted to the plasma
membrane at cell-cell interfaces where it forms
gap junction channels