The Leishmaniases

1
The Leishmaniases

• A diverse group of protozoan parasites
• Intracellular pathogens of the macrophage
• Different clinical manifestations / syndromes
• Zoonosis
• Sand fly insect vector
• Mammalian reservoir(s)
• Man is incidental host
• Indian VL caused by L. donovani and
• Cutaneous Leishmaniasis (CL) caused by L.
  tropica are exceptions

2
Parasite Life Cycle
3
CL caused by L. major acquired by US soldiers in
Iraq
4
Confirmed Cutaneous Leishmania Cases diagnosed at
the 520th TAML
Case 2
Case 3
Case 5
Case 6
Case 7
Case 8
Case 9
Case 10
Case 11
5
Current Situation

• Over 600 cases diagnosed to date
• Current treatment options
• Pentavalent antimony
• Intravenous, daily, IND status,
• Physical therapies
• ThermoMed device (heat Rx)
• Cryotherapy (LN2) Cryoprobe
• Continued operations in Leish areas for years
• Need a new tool in the tool box

6
Future Plans

• Dr. (COL) Alan Magill
• Science Director
• Walter Reed Army Institute of Research
• 301-319-9959
• Alan.Magill_at_na.amedd.army.mil